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152617-90-8

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152617-90-8 Structure

152617-90-8 Structure
IdentificationBack Directory
[Name]

OMEGA-GRAMMOTOXIN SIA
[CAS]

152617-90-8
[Synonyms]

GRTX
w-Grammotoxin SIA
ω-Grammotoxin SIA
ω-Grammotoxin SIA
OMEGA-GRAMMOTOXIN SIA
ASP-CYS-VAL-ARG-PHE-TRP-GLY-LYS-CYS-SER-GLN-THR-SER-ASP-CYS-CYS-PRO-HIS-LEU-ALA-CYS-LYS-SER-LYS-TRP-PRO-ARG-ASN-ILE-CYS-VAL-TRP-ASP-GLY-SER-VAL
[Molecular Formula]

C177H268N52O50S6
[MDL Number]

MFCD03457797
[Molecular Weight]

4116.73
Chemical PropertiesBack Directory
[storage temp. ]

−20°C
[solubility ]

aqueous buffer: soluble
[Sequence]

Asp-Cys-Val-Arg-Phe-Trp-Gly-Lys-Cys-Ser-Gln-Thr-Ser-Asp-Cys-Cys-Pro-His-Leu-Ala-Cys-Lys-Ser-Lys-Trp-Pro-Arg-Asn-Ile-Cys-Val-Trp-Asp-Gly-Ser-Val-NH2 (Disulfide bridge:Cys2-Cys16;Cys9-Cys21;Cys15-Cys30)
Safety DataBack Directory
[WGK Germany ]

3
Hazard InformationBack Directory
[Uses]

ω-Grammotoxin SIA (GrTx) is P/Q and N-type voltage-gated Calcium channels inhibitor. ω-Grammotoxin SIA is also a protein toxin that can be obtained from spider venom. ω-Grammotoxin SIA has the potential to study neurological diseases as well as cardiovascular diseases[1].
[References]

[1] Takeuchi K, et al. Solution structure of omega-grammotoxin SIA, a gating modifier of P/Q and N-type Ca(2+) channel. J Mol Biol. 2002 Aug 16;321(3):517-26. DOI:10.1016/s0022-2836(02)00595-8
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