| Identification | Back Directory | [Name]
evocarpine | [CAS]
15266-38-3 | [Synonyms]
evocarpine
1-methyl-2-[(Z)-tridec-8-enyl]quinolin-4-one
1-Methyl-2-[(Z)-8-tridecenyl]-4(1H)-quinolone
1-Methyl-2-(8Z)-8-tridecenyl-4(1H)-quinolinone
1-Methyl-2-[(Z)-8-tridecenyl]-4(1H)-quinolinone
1-Methyl-2-[(Z)-8-tridecenyl]quinoline-4(1H)-one
4(1H)-Quinolinone,1-Methyl-2-(8Z)-8-tridecen-1-yl-
(Z)-1-Methyl-2-(tridec-8-en-1-yl)quinolin-4(1H)-one
1-Methyl-2-[(Z)-8-tridecene-1-yl]quinoline-4(1H)-one | [Molecular Formula]
C23H33NO | [MDL Number]
MFCD22125019 | [MOL File]
15266-38-3.mol | [Molecular Weight]
339.51 |
| Chemical Properties | Back Directory | [Melting point ]
34-38℃ | [Boiling point ]
456.2±45.0 °C(Predicted) | [density ]
0.975±0.06 g/cm3 (20 ºC 760 Torr) | [storage temp. ]
2-8°C | [form ]
Solid | [pka]
2.52±0.70(Predicted) | [color ]
White to off-white | [CAS DataBase Reference]
15266-38-3 |
| Hazard Information | Back Directory | [Chemical Properties]
White crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO. It is derived from Evodia rutaecarpa (Juss.) Benth. | [Uses]
Evocarpine, a quinolone alkaloid that could be isolated from Evodiae fructus, inhibitss Ca2+ influx through voltage-dependent calcium channels. Antimycobacterial activity[1][2]. | [Definition]
ChEBI: Evocarpine is a member of quinolines. | [References]
[1] J Yamahar, et al. The vasorelaxant effect of evocarpine in isolated aortic strips: mode of action. Eur J Pharmacol. 1988 Oct 11;155(1-2):139-43. DOI:10.1016/0014-2999(88)90411-6
[2] C Hochfellner, et al. Antagonistic effects of indoloquinazoline alkaloids on antimycobacterial activity of evocarpine. J Appl Microbiol. 2015 Apr;118(4):864-72. DOI:10.1111/jam.12753
[3] N Y Kim, et al. Cyclic adenosine monophosphate inhibits quinolone alkaloid evocarpine-induced apoptosis via activation of protein kinase A in human leukaemic HL-60 cells. Pharmacol Toxicol. 2000 Jul;87(1):1-5. DOI:10.1111/j.0901-9928.2000.870101.x |
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