| Identification | Back Directory | [Name]
A-METHYL-L-TRYPTOPHAN | [CAS]
153-91-3 | [Synonyms]
α-Me-DL-Trp
α-Me-DL-Trp-OH
Dl-2-Me-Trp-OH
H-DL-(ME)TRP-OH
H-a-Me-DL-Trp-OH
H-α-Me-DL-Trp-OH
α-Methyltryptophan
Tryptophan,a-methyl-
H-ALPHA-ME-DL-TRP-OH
A-METHYL-L-TRYPTOPHAN
DL-α-Methyltryptophan
DL-α-Methyltryptophan
(S)-A-METHYLTRYPTOPHAN
ALPHA-ME-DL-TRYPTOPHAN
A-methyl-dl-tryptophan
α-Methyl-DL-tryptophan
DL-ALPHA-METHYLTRYPTOPHAN
ALPHA-METHYL-DL-TRYPTOPHAN
A-METHYL-L-TRYPTOPHAN USP/EP/BP
DL-α-Methyltryptophan≥ 99% (HPLC)
α-Methyl-DL-tryptophan crystalline
DL-2-METHYL-2-AMINO-3-(3-INDOLYL)PROPIONIC ACID
2-AMino-3-(1H-indol-3-yl)-2-Methylpropanoic acid | [Molecular Formula]
C12H14N2O2 | [MDL Number]
MFCD00910281 | [MOL File]
153-91-3.mol | [Molecular Weight]
218.26 |
| Chemical Properties | Back Directory | [Melting point ]
234 °C(Solv: ethanol, 60% (64-17-5)) | [Boiling point ]
444.0±35.0 °C(Predicted) | [density ]
1.314±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO (Slightly), Methanol (Slightly, Heated) | [form ]
crystalline | [pka]
2.34±0.10(Predicted) | [color ]
light yellow | [InChI]
1S/C12H14N2O2/c1-12(13,11(15)16)6-8-7-14-10-5-3-2-4-9(8)10/h2-5,7,14H,6,13H2,1H3,(H,15,16) | [InChIKey]
ZTTWHZHBPDYSQB-UHFFFAOYSA-N | [SMILES]
CC(N)(Cc1c[nH]c2ccccc12)C(O)=O |
| Hazard Information | Back Directory | [Chemical Properties]
White to off-white powder | [Uses]
α-methyl-DL-tryptophan is used as a blocker of ATBo, an amino acid transporter whose expression is upregulated in cancer. It is also a substrate or non-transported inhibitor of the amino acid transporter PAT2 (slc36a2). | [Biochem/physiol Actions]
α-methyl-DL-tryptophan is a blocker of ATBo, an amino acid transporter whose expression is upregulated in cancer. | [in vivo]
α-Methyl-DL-tryptophan (α-MT) (2 mg/mL; administered in drinking water; continuously administered; throughout the experimental period) inhibits tumor growth in BALB/c nude mice inoculated with ZR-75-1 cells[1].
α-Methyl-DL-tryptophan (1 mg/mL; administered in drinking water; continuously administered; for 1 week) reduces body weight in wild-type mice on a high-fat diet[2].
| Animal Model: | BALB/c nude mice (female) inoculated with ZR-75-1 cells[1] | | Dosage: | 2 mg/mL | | Administration: | Administered in drinking water | | Result: | Reduced the growth of ZR-75-1 cells. Tumor size was significantly smaller than that in the control group. |
| Animal Model: | Wild-type C57BL/6 male mice fed a high-fat diet[2] | | Dosage: | 1 mg/mL | | Administration: | Administered in drinking water, continuously for 1weeks | | Result: | Led to a decrease in body weight. |
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