| Identification | Back Directory | [Name]
H-VAL-TRP-OH | [CAS]
24587-37-9 | [Synonyms]
VW
VW-2
eyeliss
VAL-TRP
H-VAL-TRP-OH
Dipeptide Val-Try
N-valyltryptophan
L-Valyl-L-tyrosine
Dipeptide-2,Eyeliss
L-VALYL-L-TRYPTOPHAN
L-Tryptophan, L-valyl-
H-VAL-TRP-OH USP/EP/BP
Dipeptide-2 Dipeptide 2
Dipeptide-2\/VW-2\/H-VAL-TRP-OH
Dipeptide-2 / Dipeptide Val-Try
Cosmetic Peptide Dipeptide-2 powder
Dipeptide Diaminobutyroyl Benzylamide/Syn Ake
(2S)-2-[(2S)-2-amino-3-methylbutanamido]-3-(1H-indol-3-yl)propanoic acid | [EINECS(EC#)]
-0 | [Molecular Formula]
C16H21N3O3 | [MDL Number]
MFCD00037947 | [MOL File]
24587-37-9.mol | [Molecular Weight]
303.36 |
| Chemical Properties | Back Directory | [Boiling point ]
604.8±55.0 °C(Predicted) | [density ]
1.268±0.06 g/cm3(Predicted) | [storage temp. ]
−20°C
| [form ]
Solid | [pka]
3.14±0.10(Predicted) | [color ]
White to off-white | [Sequence]
Val-Trp | [Cosmetics Ingredients Functions]
SKIN CONDITIONING | [InChI]
InChI=1S/C16H21N3O3/c1-9(2)14(17)15(20)19-13(16(21)22)7-10-8-18-12-6-4-3-5-11(10)12/h3-6,8-9,13-14,18H,7,17H2,1-2H3,(H,19,20)(H,21,22)/t13-,14-/m0/s1 | [InChIKey]
LZDNBBYBDGBADK-KBPBESRZSA-N | [SMILES]
C(O)(=O)[C@H](CC1C2=C(C=CC=C2)NC=1)NC(=O)[C@H](C(C)C)N |
| Hazard Information | Back Directory | [Description]
Dipeptide-2 is a tiny peptide with only two amino acids (amino acids are the building block of proteins, and peptides are a few amino acids attached together), Valine and Tryptophan. It's part of a 3 actives complex called Eyeliss (with HMC and Palmitoyl Tetrapeptide-7) that's supposed to fight under-eye bags.
The manufacturer claims that this dipeptide in Eyeliss can increase lymphatic circulation and the three actives together represent a "global approach to treating puffy eyes". The clinical study of the manufacturer with 20 people and 3% Eyeliss showed improvement after 56 days for 70% of the participants. | [Chemical Properties]
H-VAL-TRP-OH is a white or off-white lyophilized powder. | [Uses]
Dipeptide 2 (N-Valyltryptophan; Val-Trp) is a bioactive peptide with anti-aging effect and has been reported used as a cosmetic ingredient[1]. Dipeptide 2 is an angiotensin-converting Enzyme (ACE)[2]. | [Definition]
ChEBI: Val-Trp is a peptide. | [Mode of action]
Dipeptide-2 is a potent angiotensin-converting enzyme (ACE) inhibitor, which reduces vasoconstriction of blood vessels around the eyes by inhibiting ACE activity and promotes blood circulation, thus improving periorbital edema and reducing dark circles. | [References]
[1] Zhang L, et al. Cosmeceuticals and peptides. Clin Dermatol. 2009;27(5):485-494. DOI:10.1016/j.clindermatol.2009.05.013
[2] Bicak B. Structural, spectroscopic, molecular docking, ADME, molecular dynamics studies of Val-Trp dipeptide. J Biomol Struct Dyn. 2023;41(23):13873-13890. DOI:10.1080/07391102.2023.2183041 |
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