| Identification | Back Directory | [Name]
4-(4-cyclopropylnaphthalen-1-yl)-1H-1,2,4-triazole-5(4H)-thione | [CAS]
1533519-84-4 | [Synonyms]
LES10
Lesinurad INT3
LESINURAD intermdiate
Lesinurad intermediate
4-triazole-5(4H)-thione
4-(4-Cyclopropylnaphthalen-1-yl)-1H-1
4-(4-Cyclopropyl-1-naphthyl)-1,2,4-triazole-5(4H)-thione
4-(4-Cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazole-3-thiol
4-(4-cyclopropyl naphthalene-1-yl)-4 H-1,2,4- triazole-3-thiol
4-(4-cyclopropylnaphthalen-1-yl)-1H-1,2,4-triazole-5(4H)-thione
4-(4-cyclopropylnaphthalene - 1-yl)-4H-1,2, 4-triazol-3-mercapta
4-(4-Cyclopropyl-1-naphthalenyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione
4-(4-cyclopropylnaphthalen-1-yl)-2,4-dihydro-3H-1,2,4-triazole-3-thione
4- (4-cyclopropylnaphthalene - 1-yl) -1H-1,2, 4-triazole-5 (4H) -thioketone
lesinurad int.4-(4-cyclopropylnaphthalen-1-yl)-1H-1,2,4-triazole-5(4H)-thione
Sodium 2-((4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-yl)thio)acetate
4-(4-cyclopropylnaphthalen-1-yl)-1H-1,2,4-triazole-5(4H)-thione (for Lesinurad)
Rexinad Intermediate: 4- (1-cyclopropylnaphthalen-4-yl) -4H-1,2,4-triazole-3-thiol | [EINECS(EC#)]
943-285-5 | [Molecular Formula]
C15H13N3S | [MDL Number]
MFCD28404707 | [MOL File]
1533519-84-4.mol | [Molecular Weight]
267.349 |
| Chemical Properties | Back Directory | [Boiling point ]
435.2±38.0 °C(Predicted) | [density ]
1.41±0.1 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,2-8°C | [pka]
7.89±0.20(Predicted) | [Appearance]
White to off-white Powder | [InChI]
InChI=1S/C15H13N3S/c19-15-17-16-9-18(15)14-8-7-11(10-5-6-10)12-3-1-2-4-13(12)14/h1-4,7-10H,5-6H2,(H,17,19) | [InChIKey]
UFYFJMMSOUURSF-UHFFFAOYSA-N | [SMILES]
N1=CN(C2=C3C(C=CC=C3)=C(C3CC3)C=C2)C(=S)N1 | [CAS DataBase Reference]
1533519-84-4 |
| Hazard Information | Back Directory | [Chemical Properties]
Off white powder | [Uses]
4-(4-Cyclopropylnaphthalen-1-yl)-1H-1,2,4-triazole-5(4H)-thione is a reagent used in the discovery of Lesinurad, a HEK293 cell-based inhibitor. | [Synthesis]
Example 5. Preparation of 4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazole-3-thiols
To a round-bottomed flask was added N-(4-cyclopropyl-1-naphthalenyl)-2-formylhydrazine thiocarboxamide (64.0 g, 225 mmol), N,N-dimethylformamide (300 mL), and 1 mol/L aqueous sodium hydroxide solution (225 mL) to form a mixture. After stirring, the mixture was heated to 30 °C and kept for 16 hours. After the reaction was completed, the mixture was cooled to room temperature (about 20°C). Subsequently, 1 mol/L hydrochloric acid (about 200 mL) was slowly added to the mixture until the pH of the mixture was about 6.0, and then water (about 500 mL) was added. The mixture was stirred for 15 minutes and then filtered. The filter cake was washed with water and the product was dried under vacuum at 50 °C for 5 h to give 4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazole-3-thiol as a gray-green solid, 54.0 g in 90% yield.
LC-MS: m/z (ESI): 268 (M + H)+.
1H NMR (400 MHz, acetone-d6): δ 8.57 (d, J = 8.0 Hz, 1H), 8.37 (s, 1H), 7.67 (m, 1H), 7.60 (m, 1H), 7.51 (d, J = 8.0 Hz, 1H), 7.48 (d, J = 8.0 Hz, 1H), 7.43 (d, J = 8.0 Hz, 1H), 2.50 (m, 1H), 1.16 (m, 2H), 0.84 (m, 2H). | [References]
[1] Patent: WO2014/198241, 2014, A1. Location in patent: Paragraph 069-070
[2] Patent: WO2014/8295, 2014, A1. Location in patent: Paragraph 0337 |
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