ChemicalBook--->CAS DataBase List--->153436-53-4

153436-53-4

153436-53-4 Structure

153436-53-4 Structure
IdentificationBack Directory
[Name]

AG 1478 HYDROCHLORIDE
[CAS]

153436-53-4
[Synonyms]

AG-1478
AG1478HCl
NSC 693255
AG 1478 HYDROCHLORIDE
AG-1478 (Tyrphostin AG-1478)
Tyrphostin AG 1478, free base >99%
4-(3-CHLOROANILINO)-6,7-DIMETHOXYQUINAZOLINE HCL
(3-Chlorophenyl)(6,7-dimethoxyquinazolin-4-yl)amine
4-(3-CHLOROANILINO)-6,7-DIMETHOXYQUINAZOLINE HYDROCHLORIDE
N-(3-CHLOROPHENYL)-6,7-DIMETHOXY-4-QUINAZOLINANINE HYDROCHLORIDE
[Molecular Formula]

C16H15Cl2N3O2
[MDL Number]

MFCD06804597
[MOL File]

153436-53-4.mol
[Molecular Weight]

352.22
Chemical PropertiesBack Directory
[Melting point ]

247 °C(dec.)
[Boiling point ]

458.5±45.0 °C(Predicted)
[density ]

1.337
[storage temp. ]

Desiccate at-20°C
[form ]

White to light yellow solid.
[pka]

5.54±0.30(Predicted)
[λmax]

332nm(lit.)
Hazard InformationBack Directory
[Usage]

A highly potent and specific EGFR tyrosine kinase inhibitor with an IC50 of 3 nM.
[Biological Activity]

Potent and selective inhibitor of epidermal growth factor receptor kinase (IC 50 values 3 nM for EGFR and > 100 μ M for ErbB2 and PDGFR). Inhibits proliferation of NCI-H2170 NSCLC cells in vitro (IC 50 = 1 μ M).
[Uses]

A highly potent and specific EGFR tyrosine kinase inhibitor with an IC50 of 3 nM.
Safety DataBack Directory
[RTECS ]

VA0953000
[HS Code ]

29339900
Spectrum DetailBack Directory
[Spectrum Detail]

AG 1478 HYDROCHLORIDE(153436-53-4)1HNMR
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