| Identification | Back Directory | [Name]
4-Bromo-5-fluoro-2-nitroaniline | [CAS]
153505-36-3 | [Synonyms]
4-Bromo-5-fluoro-2-nitroaniline
4-Bromo-5-fluoro-2-nitroaniline97%
4-Bromo-5-fluoro-2-nitroaniline 97%
2-Amino-5-bromo-4-fluoronitrobenzene
Benzenamine,4-bromo-5-fluoro-2-nitro- | [Molecular Formula]
C6H4BrFN2O2 | [MDL Number]
MFCD11101433 | [MOL File]
153505-36-3.mol | [Molecular Weight]
235.01 |
| Chemical Properties | Back Directory | [Boiling point ]
313.9±37.0 °C(Predicted) | [density ]
1.896±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [pka]
-2.19±0.25(Predicted) | [Appearance]
Light yellow to yellow Solid |
| Hazard Information | Back Directory | [Synthesis]
The general procedure for the synthesis of 4-bromo-5-fluoro-2-nitroaniline, using the compound (CAS: 929279-27-6) as starting material, was as follows:Preparation of Intermediate 11B: To (4-bromo-5-fluoro-2-nitrophenyl)-2,2,2-trifluoroacetamide (3.5 g, 10.5 mmol) was added methanol (30 mL), followed by potassium carbonate (1.0 M 10.5 mL, 10.5 mmol). The reaction mixture was stirred for 30 min (Ref. Charifson, PS; et al. J. Med. Chem. 2008, 51, 5243-5263). Upon completion of the reaction, the reaction solution was diluted with deionized water and stirring was continued for 1 hour. The resulting orange solid was collected by filtration and dried in a vacuum oven to give the final target product 4-bromo-5-fluoro-2-nitroaniline (2.1 g, 8.8 mmol, 84% yield). | [References]
[1] Patent: WO2012/83170, 2012, A1. Location in patent: Page/Page column 154-155
[2] Tetrahedron Letters, 2008, vol. 49, # 44, p. 6348 - 6351
[3] Patent: WO2007/30366, 2007, A1. Location in patent: Page/Page column 121
[4] Patent: US2007/259936, 2007, A1. Location in patent: Page/Page column 175 |
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| Company Name: |
Energy Chemical
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| Tel: |
021-021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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