| Identification | More | [Name]
5-FLUORO-DL-TRYPTOPHAN | [CAS]
154-08-5 | [Synonyms]
2-AMINO-3-(5-FLUORO-1H-INDOL-3-YL)PROPANOIC ACID
5-FLUORO-DL-TRYPTOPHAN
DL-2-AMINO-3-(5-FLUOROINDOLYL)PROPIONIC ACID
DL-5-FLUOROTRYPTOPHAN
H-5-FLUORO-DL-TRP-OH
H-DL-TRP(5-F)-OH
TIMTEC-BB SBB003340
5-fluorotryptophan
5-Fluoro-DL-tryptophan, 99+%
5-Fluoro-DL-tryptophan 98%
5-Fluoro-DL-tryptophan98%
5-Fluoro-DL-tryptophane
H-Trp(5-F)-OH | [EINECS(EC#)]
205-822-5 | [Molecular Formula]
C11H11FN2O2 | [MDL Number]
MFCD00005649 | [Molecular Weight]
222.22 | [MOL File]
154-08-5.mol |
| Chemical Properties | Back Directory | [Appearance]
light beige powder | [Melting point ]
265 °C (dec.)(lit.) | [Boiling point ]
450.7±45.0 °C(Predicted) | [density ]
1.2556 (estimate) | [storage temp. ]
2-8°C
| [form ]
powder
| [pka]
2.21±0.10(Predicted) | [color ]
white
| [Usage]
A metabolic antagonist of tryptophan | [BRN ]
22753 | [InChIKey]
INPQIVHQSQUEAJ-UHFFFAOYSA-N | [CAS DataBase Reference]
154-08-5(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/38:Irritating to eyes and skin . | [Safety Statements ]
S22:Do not breathe dust .
S24/25:Avoid contact with skin and eyes . | [WGK Germany ]
3
| [RTECS ]
YN6825000
| [Hazard Note ]
Irritant | [HS Code ]
29339900 |
| Hazard Information | Back Directory | [Chemical Properties]
light beige powder | [Uses]
A metabolic antagonist of tryptophan | [Definition]
ChEBI: A non-proteinogenic alpha-amino acid that is tryptophan in which the hydrogen at position 5 on the indole ring is replaced by a fluoro group. | [Biological Activity]
5-Fluoro-DL-tryptophan (5-F-TRP)a fluorine-containing analogue of tryptophanmay be incorporated into proteins such as cyclic AMP receptor protein (CRP) from Escherichia coli to study changes in ligand binding. 5-F-TRP may be used as an internal reference for chromatographic analysis of tryptophan and its derivatives found in whole blood. | [Purification Methods]
Recrystallise it from EtOH, aqueous EtOH or AcOH. Also purify it by passage through a Dowex AG1x2 (acetate form) column and recrystallise the L-enantiomer (from enzymic enrichment) from H2O/EtOH, m 158-163o(dec), [] D -8.3o (c 2.5, N NaOH). [Coy et al. Biochemistry 13 3550 1974, Beilstein 22/14 V 116.] |
|
|