| Identification | Back Directory | [Name]
1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-hydroxy-4-oxo-3-quinolinecarboxylic Acid | [CAS]
154093-72-8 | [Synonyms]
154093-72-8
Mosisasin Impurity E2
Gatifloxacin USP RC B
Moxifloxacin Impurity 23
1-cyclopropyl-6,7-difluoro
Gatifloxacin USP IMpurity B
Difluorohydroxy gatifloxacin
Gatifloxacin hydroxy acid impurity
Moxifloxacin Difluoro Hydroxy Impurity
Moxifloxacin hydroxyquinoline impurities
Moxifloxacin Difluoro Hydroxy Acid Impurity
Gatifloxacin Related Compound B/Moxifloxacin Difluoro Hydroxy Acid Impurity
Moxifloxacin Difluoro Hydroxy Acid Impurity (Gatifloxacin Related Compound B)
1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-hydroxy-4-oxo-3-quinolinecarboxylic Acid
1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-hydroxy-4-oxo-quinolin-3-carboxylic acid
1-cyclopropyl-6,7-difluoro-8-hydroxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
3-Quinolinecarboxylic acid, 1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-hydroxy-4-oxo-
Moxifloxacin impurity 18/Moxifloxacin Hydroxy Quinoline Impurity/1-Cyclopropyl-6,7-difluoro-8-hydroxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid | [Molecular Formula]
C13H9F2NO4 | [MDL Number]
MFCD25973506 | [MOL File]
154093-72-8.mol | [Molecular Weight]
281 |
| Chemical Properties | Back Directory | [Melting point ]
>271oC (dec.) | [Boiling point ]
478.3±45.0 °C(Predicted) | [density ]
1.745±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
DMSO (Slightly), Methanol (Slightly, Heated) | [form ]
Solid | [pka]
5.75±0.20(Predicted) | [color ]
White to Pale Beige |
| Hazard Information | Back Directory | [Uses]
Moxifloxacin (M745000) | [Synthesis]
About 500 mL of DMSO filtrate from the nucleophilic substitution reaction was transferred to a 1000 mL reactor and anhydrous calcium chloride (about 33 g) was added under stirring conditions. The reaction mixture was cooled with stirring to 0-5 °C and maintained in this temperature range for 30 minutes. Subsequently, the pH was adjusted to 4 with a 15% aqueous hydrochloric acid solution, the temperature was maintained between 0-5°C, and stirring was continued for 3 hours. Upon completion of the reaction, the precipitated product was collected by filtration, washed well with acetone and then dried. A dry 1-cyclopropyl-6,7-difluoro-8-hydroxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (about 35 g) with a purity of more than 90% was finally obtained. | [References]
[1] Patent: WO2006/4561, 2006, A1. Location in patent: Page/Page column title page; 4; 12-13
[2] Patent: WO2008/62379, 2008, A2. Location in patent: Page/Page column 37
[3] Patent: US2010/222302, 2010, A1. Location in patent: Page/Page column 21
[4] Patent: WO2007/17828, 2007, A2. Location in patent: Page/Page column 54 |
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J & K SCIENTIFIC LTD.
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parabiochem
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www.parabiochem.cn |
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Cck Pharmchem Co.,Ltd
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