Identification | More | [Name]
1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid | [CAS]
112811-72-0 | [Synonyms]
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid 1-CYCLOPROPYL-6,7-DIFLUORO-8-METHOXY-4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC ACID 1-CYCLOPROPYL-6,7-DIFLUORO-8-METHOXY-4-OXO-3-QUINOLINECARBOXYLIC ACID 3-QUINOLINECARBOXYLIC ACID, 1-CYCLOPROPYL-6,7-DIFLUORO-1,4-DIHYDRO-8-METHOXY-4-OXO- 1-Cyclopropyl6,7Dihydro-8-Methoxy-4-Oxo-3-QuinoiineCarboxylicAcid,MoxifloxacinHcl 1-Cyclo Propyl-6,7-Difluoro-1,4-Dihydro-8-Methoxy-4-Oxo-3-Quinoiinearboxylic acid 1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic Aci 1-Cyclopropyl-6,7-difluoro-8-methoxy-4-oxo-3-quinolinecarboxylic | [EINECS(EC#)]
601-205-3 | [Molecular Formula]
C14H11F2NO4 | [MDL Number]
MFCD05864420 | [Molecular Weight]
295.24 | [MOL File]
112811-72-0.mol |
Chemical Properties | Back Directory | [Appearance]
Off-White to Light-Yellow Powder | [Melting point ]
192-194°C | [Boiling point ]
474.4±45.0 °C(Predicted) | [density ]
1.581±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
Chloroform (Slightly), Methanol (Slightly, Sonicated) | [form ]
Solid | [pka]
6.36±0.50(Predicted) | [color ]
White to Pale Beige | [Usage]
Moxifloxacin intermediate | [InChI]
InChI=1S/C14H11F2NO4/c1-21-13-10(16)9(15)4-7-11(13)17(6-2-3-6)5-8(12(7)18)14(19)20/h4-6H,2-3H2,1H3,(H,19,20) | [InChIKey]
WQJZXSSAMGZVTM-UHFFFAOYSA-N | [SMILES]
N1(C2CC2)C2=C(C=C(F)C(F)=C2OC)C(=O)C(C(O)=O)=C1 | [CAS DataBase Reference]
112811-72-0(CAS DataBase Reference) |
Hazard Information | Back Directory | [Chemical Properties]
Off-White to Light-Yellow Powder | [Uses]
Moxifloxacin intermediate | [Synthesis]
General Steps:
Reaction: in a 250 mL round bottom flask, 10 g of ethyl 1-cyclopropyl-6,7-difluoro-8-methoxy-4-yloxy-1,4-dihydroxyquinoline-3-carboxylate (compound of formula 2) and 100 mL of anhydrous methanol were added and stirred until completely dissolved. Subsequently, 13.3 mL of 36% hydrochloric acid was added slowly and dropwise. After addition, the reaction system was heated to 65 °C and the reaction was stirred at this temperature for 15 hours.
Post-treatment: after completion of the reaction, the system was cooled to 10 °C and stirring was continued for 2 hours to promote crystallization. Subsequently, the system was filtered under reduced pressure. The filter cake was washed with 20 mL of anhydrous methanol and subsequently dried under vacuum at 60 °C for 8 h to afford 8.86 g of 1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid (compound of formula 3) in 96.83% yield. | [References]
[1] Patent: CN107778308, 2018, A. Location in patent: Paragraph 0067; 0068; 0069 [2] Asian Journal of Chemistry, 2013, vol. 25, # 11, p. 6079 - 6082 [3] Bioorganic and Medicinal Chemistry, 2008, vol. 16, # 5, p. 2558 - 2569 [4] Patent: US4997943, 1991, A [5] Patent: WO2004/14893, 2004, A2. Location in patent: Page 75; 76 |
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