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343268-91-7

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343268-91-7 Structure

343268-91-7 Structure
IdentificationBack Directory
[Name]

Orexin A (17-33)
[CAS]

343268-91-7
[Synonyms]

OXA (17-33)
Orexin A (17-33)
[Molecular Formula]

C79H125N23O22
[MDL Number]

MFCD30182260
[MOL File]

343268-91-7.mol
[Molecular Weight]

1748.98
Chemical PropertiesBack Directory
[Boiling point ]

2099.4±65.0 °C(Predicted)
[density ]

1.287±0.06 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[form ]

Powder
[pka]

4.42±0.10(Predicted)
[color ]

White to off-white
[Water Solubility ]

Soluble to 1 mg/ml in water
[Sequence]

Tyr-Glu-Leu-Leu-His-Gly-Ala-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Leu-NH2
Hazard InformationBack Directory
[Uses]

OXA(17-33) is a potent and selective orexin-1 receptor (OX1) agonist. OXA(17-33) shows a ～23-fold selectivity for the OX1 (EC50=8.29 nM) over OX2 (187 nM)[1].
[IC 50]

OX1: 8.29 nM (EC50); OX2: 187 nM (EC50)
[storage]

Store at -20°C
[References]

[1] German NA, et al. Truncated Orexin Peptides: Structure-Activity Relationship Studies. ACS Med Chem Lett. 2013;4(12):1224-1227. DOI:10.1021/ml400333a
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