| Identification | Back Directory | [Name]
Ampalex | [CAS]
154235-83-3 | [Synonyms]
CX 516
Ampalex
Ampalex, >=98%
AMpakine CX516
BDP-12(Ampalex)
AMpalex (CX-516)
CX516; BDP 12; AMPAKINE CX516
SPD-420, BDP-12, CX-516, AMpalex
1-(6-Quinoxalinylcarbonyl)piperidine
1-Piperidinyl-6-quinoxalinylMethanone
1-(QUINOXALIN-6-YLCARBONYL)PIPERIDINE
6-(piperidin-1-ylcarbonyl)quinoxaline
Piperidine, 1-(6-quinoxalinylcarbonyl)-
Piperidin-1-yl-quinoxalin-6-ylmethanone
Methanone, 1-piperidinyl-6-quinoxalinyl-
ABT-224,PIPERIDINE, 1-(6-QUINOXALINYLCARBONYL)-
Ampalex
1-(Quinoxalin-6-ylcarbonyl)piperidine | [EINECS(EC#)]
200-256-5 | [Molecular Formula]
C14H15N3O | [MDL Number]
MFCD00943201 | [MOL File]
154235-83-3.mol | [Molecular Weight]
241.29 |
| Questions And Answer | Back Directory | [Synthesis]
Low molecular weight polyethylene glycol (PEG, HO-(CH2CH2O)nH) is widely used as an environmentally friendly solvent and phase transfer catalyst due to its high thermal stability, low volatility, non-flammability, low cost, and biodegradability, and is extensively applied in organic synthesis. The "one-pot" method, which eliminates the need for intermediate product separation, greatly improves atom utilization and is a very promising organic synthesis method. Furthermore, ferric nitrate is an excellent oxidant and catalyst in organic synthesis, and it is abundant, inexpensive, and causes minimal environmental pollution. Our laboratory previously reported that Fe(NO3)3·9H2O/AcOH-PEG400 can easily, conveniently, and efficiently synthesize alcohols and ketones, and can be further condensed with o-phenylenediamine to obtain quinoxaline. The reaction formula for the preparation of Ampalex is shown in the figure below: 
Figure 1. Reaction formula for the preparation of Ampalex |
| Chemical Properties | Back Directory | [Melting point ]
88-90°C | [Boiling point ]
433.1±25.0 °C(Predicted) | [density ]
1.236±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
Chloroform, Methanol | [form ]
powder | [pka]
-0.14±0.30(Predicted) | [color ]
white to light brown | [Water Solubility ]
H2O: 5mg/mL, clear | [InChI]
1S/C14H15N3O/c18-14(17-8-2-1-3-9-17)11-4-5-12-13(10-11)16-7-6-15-12/h4-7,10H,1-3,8-9H2 | [InChIKey]
ANDGGVOPIJEHOF-UHFFFAOYSA-N | [SMILES]
O=C(C1=CC2=NC=CN=C2C=C1)N3CCCCC3 |
| Safety Data | Back Directory | [WGK Germany ]
WGK 3 | [RTECS ]
TM2785170 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Acute Tox. 4 Oral |
| Hazard Information | Back Directory | [Chemical Properties]
Tan Solid | [Uses]
It is one of a series of AMPA modulators | [Definition]
ChEBI: CX-516 is a N-acylpiperidine. | [Biochem/physiol Actions]
CX516 is a positive allosteric modulator at AMPA receptor that inhibits the deactivation of AMPA receptors. CX-516 is a nootropic and ampakine agent. | [in vivo]
The specific extradimensional deficits produced by sub-chronic or early postnatal postnatal phencyclidine treatment were significantly attenuated by CX516 (10, and 20 mg/kg, s.c.)[1]. | Animal Model: | Male Lister Hooded rats (56-63 postnatal day)[1] | | Dosage: | 5, 10, 20, and 40 mg/kg | | Administration: | Subcutaneously | | Result: | Two doses (10 and 20 mg/kg) were highly significant in improving the extradimensional shift deficit induced by either treatment regimes.
Two doses (5 and 40 mg/kg) was ineffective at reversing the extradimensional impairment induced by the sub-chronic postnatal phencyclidine treatment regime. |
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| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Shanghai Ennopharm Co., Ltd.
|
| Telephone: |
+86 (21) 6435-5022 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList13640/0_EN.htm |
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