| Identification | Back Directory | [Name]
3-Chlorosulfonyl-propionic acid methyl ester | [CAS]
15441-07-3 | [Synonyms]
Methyl 3-chlorosulfonylpropionate
3-Methoxy-3-oxopropanesulfonyl chloride
3-Chlorosulfonyl-propionic acid methyl ester
Propanoic acid, 3-(chlorosulfonyl)-, methyl ester | [Molecular Formula]
C4H7ClO4S | [MDL Number]
MFCD07339056 | [MOL File]
15441-07-3.mol | [Molecular Weight]
186.61 |
| Chemical Properties | Back Directory | [Boiling point ]
110-113 °C(Press: 4 Torr) | [density ]
1.430±0.06 g/cm3(Predicted) | [storage temp. ]
under inert gas (nitrogen or Argon) at 2-8°C | [Appearance]
Colorless to light yellow Liquid |
| Hazard Information | Back Directory | [Synthesis]
Methyl 3-mercaptopropionate (6.5 g, 54 mmol) was dissolved in dichloromethane under cooling conditions in an ice bath, and chlorine was slowly passed through until the reaction solution took on a light green color. After continuing to pass the chlorine gas for 0.5 h, the reaction was purged with nitrogen to remove unreacted chlorine gas. The reaction mixture was extracted with dichloromethane, the organic phases were combined and washed with saturated brine, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give methyl 3-(chlorosulfonyl)propionate (9.7 g, 96% yield). | [References]
[1] Patent: TW2017/36341, 2017, A. Location in patent: Paragraph 0173-0175
[2] Patent: US2017/183318, 2017, A1. Location in patent: Paragraph 0201; 0202
[3] Patent: US2012/71466, 2012, A1. Location in patent: Page/Page column 13
[4] Patent: EP2439202, 2012, A1. Location in patent: Page/Page column 17 |
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