| Identification | Back Directory | [Name]
PROTOPORPHYRINATO ZINC | [CAS]
15442-64-5 | [Synonyms]
ZnPP
PROTOPORPHYRINATO ZINC
Zinc protoporphyrin trihydrate
Zinc protoporphyrin trihydrate, 95+%
PROTOPORPHYRINATO ZINC ISO 9001：2015 REACH
Zinc Protoporphyrin IX
DISCONTINUED, offer Z439970
Zinc (II) Protoporphyrin IX - CAS 15442-64-5 - Calbiochem
Zinc(II) 3,3'-(3,8,13,17-tetramethyl-7,12-divinylporphyrin-2,18-diyl)dipropionate
dihydrogen [3,8,13,17-tetramethyl-7,12-divinyl-21H,23H-porphine-2,18-dipropionato(4-)-N21,N22,N23,N24]zincate(4-) | [EINECS(EC#)]
239-455-7 | [Molecular Formula]
C34H32N4O4Zn | [MDL Number]
MFCD03427473 | [MOL File]
15442-64-5.mol | [Molecular Weight]
626.03 |
| Chemical Properties | Back Directory | [RTECS ]
ZG9210300 | [storage temp. ]
Store at RT | [solubility ]
DMSO : 50 mg/mL (79.87 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble) | [form ]
Crystalline | [color ]
Dark red to purple | [Water Solubility ]
Insoluble in water. Soluble in ethanol, and DMSO, pyridine, or dimethyl formamide. | [ε(extinction coefficient)]
≥10000 at 585-591nm in pyridine
≥12000 at 548-554nm in pyridine
≥135000 at 423-429nm in pyridine | [λmax]
426 nm | [Stability:]
Hygroscopic | [InChIKey]
FUTVBRXUIKZACV-RGGAHWMASA-K | [SMILES]
C(C1C(=C2C=C3C(C=C)=C(C)C4C=C5C(C=C)=C(C)C6=CC7C(C)=C(CCC(=O)[O-])C8N=7[Zn+2]([N-]56)(N3=4)[N-]2C=1C=8)C)CC(=O)[O-].[H+] | [EPA Substance Registry System]
Zincate(2-), [7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-.kappa.N21,.kappa.N22,.kappa.N23,.kappa.N24]-, dihydrogen, (SP-4-2)- (15442-64-5) |
| Hazard Information | Back Directory | [Uses]
Potent and selective inhibitor of heme oxygenase (Ki=3nM), the enzyme that generates carbon monoxide (CO). Inhibits soluble guanylyl cyclase. Produces a time- and concentration-dependent inactivation of all three isoforms of nitric oxide synthase (IC50=0.8μM, 4.0μM, and 5.0μM for nNOS (NOS I), iNOS (NOS II) and eNOS (NOS III), respectively). Does not cross the blood-brain barrier. An useful tool to elucidate the role of CO in signal transduction and as a neurotransmitter. | [General Description]
A potent and selective inhibitor of heme oxygenase, the enzyme which generates carbon monoxide (CO) and biliverdin. Inhibits soluble guanylyl cyclase and produces a time- and concentration-dependent inactivation of all three isoforms of nitric oxide synthase (IC50 = 800 nM, 4 μM, and 5 μM for nNOS, iNOS, and eNOS, respectively). Inhibits relaxation induced by acetylcholine, ANP, and VIP in isolated rat aorta. Blocks interleukin-1 and prevents induction of long-term potentiation. Also useful as an indicator of iron-deficient erythropoiesis. Does not cross the blood-brain barrier. | [Biological Activity]
Inhibitor of heme oxygenase, which generates the putative neurotransmitter CO. | [Biochem/physiol Actions]
Primary Targetheme oxygenase | [in vivo]
Zinc Protoporphyrin (12.5, 25, 50 mg/kg for i.p.; 12.5, 50 mg/kg for p.o.; from day 7 to 19) exerts dose-dependent antitumor effects manifested by the retardation of tumor growth[3].
| Animal Model: | BALB/c mice inoculated with C-26 cells[3] | | Dosage: | 12.5, 25, 50 mg/kg for i.p.; 12.5, 50 mg/kg for p.o. | | Administration: | IP or PO; from day 7 to 19 | | Result: | Exerted dose-dependent antitumor effects manifested by the retardation of tumor growth.
|
| [IC 50]
Human Endogenous Metabolite |
|
| Company Name: |
Alfa Aesar
|
| Tel: |
400-6106006 |
| Website: |
http://chemicals.thermofisher.cn |
| Company Name: |
Energy Chemical
|
| Tel: |
021-021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
|