| Identification | More | [Name]
N,N-Bis(trimethylsilyl)formamide | [CAS]
15500-60-4 | [Synonyms]
BIS-N N-(TRIMETHYLSILYL)FORMAMIDE
BSF
N,N-BIS(TRIMETHYLSILYL)FORMAMIDE
n,n-bis(trimethylsilyl)-formamid
N,N-Bis-(trimethylsilyl)-formamide(BSF)
BIS-N N-(TRIMETHYLSILYL)FORMAMIDE 97% | [EINECS(EC#)]
239-530-4 | [Molecular Formula]
C7H19NOSi2 | [MDL Number]
MFCD00014849 | [Molecular Weight]
189.4 | [MOL File]
15500-60-4.mol |
| Hazard Information | Back Directory | [Physical properties]
81–82 °C/20 mmHg; 154 °C/760 mmHg;
mp 16–17 °C; n20
D 1.4388. | [Uses]
N,N-Bis(trimethylsilyl)formamide can be used as source of nucleophilic formamide and N-silylaldimine synthon.
N,N-Bis(trimethylsilyl)formamide (BSF) exists in the amide form with both silyl groups attached to the nitrogen atom. This is in contrast to most other bis(TMS)amides (e.g., bis(TMS)- acetamide), which favor the N,O-bis(TMS)imidate isomer. BSF behaves as an N-formamido nucleophile, reacting with the carbonyl group of aldehydes and activated ketones to give N-formyl-O-trimethylsilyl-N,O-acetals. Similarly, reaction with imines (or their precursors) can in some cases give N-formylN,N-acetals. BSF undergoes reactions with a range of other electrophiles including acid chlorides, chloroformate esters, and isocyanates to give a range of interesting products. When treated with organolithium nucleophiles, attack occurs at the carbonyl function, to provide N-silylaldimines after elimination of a silyloxy unit. Such imines are reported to undergo further reactions to give heterocycles. There are also reports of BSF acting as a silylating agent, to give silyl enol ethers, although it is not commonly used for this application. | [Preparation]
chlorotrimethylsilane was added at room
temperature to a solution of formamide and triethylamine in
dry benzene and the mixture was heated at reflux for 1 h. The
reaction mixture was filtered, and the filtrate was evaporated to
give a crude oil. This was purified by high-vacuum distillation
to afford N,N-bis(trimethylsilyl)formamide (BSF) as an oil in
75% yield.
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