| Identification | Back Directory | [Name]
N-(3,4-dichlorophenyl)-N-methylpropionamide | [CAS]
15533-81-0 | [Synonyms]
ELP-004
N-(3,4-dichlorophenyl)-N-methylpropanamide
N-(3,4-dichlorophenyl)-N-methylpropionamide
Propanamide, N-(3,4-dichlorophenyl)-N-methyl- | [Molecular Formula]
C10H11Cl2NO | [MOL File]
15533-81-0.mol | [Molecular Weight]
232.11 |
| Hazard Information | Back Directory | [Uses]
ELP-004 is a TRPC channel inhibitor and inhibtis TRPC channel-mediated Ca2+ entry. ELP-004 is an osteoclast inhibitor and inhibits osteoclast differentiation. ELP-004 inhibits basal Ca2+ and related NFATc1 translocation in inflammatory osteoclastogenesis. ELP-004 reduces bone erosion in a mouse model of rheumatoid arthritis[1][2]. | [References]
[1] Ray S, et al. Targeting TRPC channels for control of arthritis-induced bone erosion. Sci Adv. 2025 Jan 17;11(3):eabm9843. DOI:10.1126/sciadv.abm9843
[2] McCall JL, et al. Preclinical evaluation of ELP-004 in mice. Pharmacol Res Perspect. 2024 Aug;12(4):e1230. DOI:10.1002/prp2.1230 |
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