| Identification | Back Directory | [Name]
3-(4-(1,2-diphenylbut-1-enyl)phenyl)acrylic acid | [CAS]
155701-61-4 | [Synonyms]
DPC974
DPC-974
GW-5638
DPC 974
Etacstil
3-(4-(1,2-diphenylbut-1-enyl)phenyl)acrylic acid
2-Propenoic acid, 3-[4-[(1Z)-1,2-diphenyl-1-buten-1-yl]phenyl]-, (2E)- | [Molecular Formula]
C25H22O2 | [MOL File]
155701-61-4.mol | [Molecular Weight]
354.44 |
| Hazard Information | Back Directory | [Uses]
Etacstil (GW5638) is a estrogen receptor antagonist that displays minimal uterotropic activity in ovariectomized rats and inhibits the agonist activity of Estradiol (HY-B0141), Tamoxifen (HY-13757A) and Raloxifene (HY-13738) in the environment. Etacstil is promising for research of breast cancer and bone protection[1]. | [References]
[1] Willson TM, et al. Dissection of the molecular mechanism of action of GW5638, a novel estrogen receptor ligand, provides insights into the role of estrogen receptor in bone. Endocrinology. 1997 Sep;138(9):3901-11. DOI:10.1210/endo.138.9.5358 |
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