Back to ChemicalBook Home--->CAS DataBase List--->50-28-2

50-28-2

50-28-2 Structure

50-28-2 Structure
IdentificationMore
[Name]

Estradiol
[CAS]

50-28-2
[Synonyms]

17BETA-ESTRADIOL-16,16,17-D3
BETA-ESTRADIOL-16,16,17-D3
(+)-3,17β-estradiol
(17b)-estra-1,3,5(10)-triene-3,17diol
(17β)-estra-1,3,5(10)-triene-3,17diol
.alpha.-Oestradiol
.beta.-Oestradiol
17-.beta.-Estra-1,3,5(10)-triene-3,17-diol
17-.beta.-Oestra-1,3,5(10)-triene-3,17-diol
17-beta-estra-1,3,5(10)-triene-3,17-diol
17beta-Estra-1,3,5(10)-triene-3,17-diol
17-beta-oestra-1,3,5(10)-triene-3,17-diol
17beta-Oestra-1,3,5(10)-triene-3,17-diol
17-beta-oh-estradiol
17beta-OH-estradiol
17-beta-oh-oestradiol
17beta-OH-oestradiol
17β-estradiol
3,17-.beta.-Dihydroxy-1,3,5(10)-oestratriene
3,17-.beta.-Dihydroxyestra-1,3,5(10)-triene
[EINECS(EC#)]

200-023-8
[Molecular Formula]

C18H24O2
[MDL Number]

MFCD01074033
[Molecular Weight]

272.38
[MOL File]

50-28-2.mol
Chemical PropertiesBack Directory
[Appearance]

Estradiol, 17-β-is an odorless white to yellow crystalline substance.
[Appearance]

White Crystalline Powder
[Melting point ]

178-179 °C(lit.)
[mp ]

178-179 °C(lit.)
[Boiling point ]

355.44°C (rough estimate)
[alpha ]

D25 +76 to +83° (dioxane)
[density ]

1.0708 (rough estimate)
[refractive index ]

80.4 ° (C=1, Dioxane)
[Fp ]

2℃
[storage temp. ]

2-8°C
[form ]

powder
[color ]

White to off-white
[Stability:]

Stable. Incompatible with strong oxidizing agents.
[Water Solubility ]

Soluble in dimethyl sulfoxide, ethanol , water, phosphate buffer saline, dimethyl formamide, acetone, dioxane and alkali hydroxides. Slightly soluble in vegetable oils.
[Usage]

Potent mammalian estrogenic hormone produced by the ovary.
[Merck ]

14,3703
[BRN ]

1914275
[Contact allergens]

Natural estradiol, used in transdermal systems for hormonal substitution, can induce allergic contact dermatitis, with the risk of systemic contact dermatitis after oral reintroduction.
[InChIKey]

VOXZDWNPVJITMN-ZBRFXRBCSA-N
[CAS DataBase Reference]

50-28-2(CAS DataBase Reference)
[NIST Chemistry Reference]

Estra-1,3,5(10)-triene-3,17beta-diol(50-28-2)
[EPA Substance Registry System]

50-28-2(EPA Substance)
Hazard InformationBack Directory
[Chemical Properties]

White Crystalline Powder
[Uses]

Potent mammalian estrogenic hormone produced by the ovary.
[Uses]

Estradiol is the major estrogen secreted by the premenopausal ovary.
[Definition]

ChEBI: The 17beta-isomer of estradiol.
[Hazard]

A carcinogen (OSHA).
[Biological Activity]

Endogenous estrogen receptor (ER) agonist (K i values are 0.12 and 0.13 nM for ER α and ER β respectively). Also high affinity ligand at membrane estrogen GPR30 receptors.
[Potential Exposure]

The working environment may be contaminated during sex hormone manufacture, especially during the extraction and purification of natural steroid hormones; grinding of raw materials; handling of powdered products and recrystallization. Airborne particles of sex hormones may be absorbed through the skin, ingested or inhaled. Enteric absorption results in quick inactivation of sex hormones in the liver. The rate of inactivation is decreased for the oral, alkylated steroid hormones (methyl testosterone, anabolic steroids, etc.). Sex hormones may accumulate and reach relatively high levels even if their absorption is intermittent. Consequently, repeated absorption of small amounts may be detrimental to health. Intoxication by sex hormones may occur in almost all the exposed workers if preventive measures are not taken. The effect in the industrial sector is more successful than the agricultural one (chemical caponizing of cockerels by stilbestrol implants and incorporation of estrogens in feed for body weight gain promotion in beef cattle), where measures taken are summary and the number of cases of intoxication is consequently bigger
[First aid]

If this chemical gets into the eyes, remove any contact lenses at once and irrigate immediately for at least 15 minutes, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts the skin, remove contaminated clothing and wash immediatelywith soap and water. Seek medical attention immediately. If this chemical has been inhaled, remove from exposure, begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR if heart action has stopped. Transfer promptly to a medical facility. When this chemical has been swallowed, get medical attention. Give large quantities of water and induce vomiting. Do not make an unconscious person vomit
[Shipping]

UN3249 Medicine, solid, toxic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials
Safety DataBack Directory
[Hazard Codes ]

T
[Risk Statements ]

R60:May impair fertility.
R61:May cause harm to the unborn child.
R45:May cause cancer.
R63:Possible risk of harm to the unborn child.
[Safety Statements ]

S53:Avoid exposure-obtain special instruction before use .
S22:Do not breathe dust .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
[RIDADR ]

2811
[WGK Germany ]

3
[RTECS ]

KG2975000
[F ]

8-10
[HazardClass ]

6.1
[PackingGroup ]

III
[HS Code ]

29372300
[Safety Profile]

Confirmed carcinogen with experimental carcinogenic, neoplastigenic, tumorigenic, and teratogenic data. A promoter. Human reproductive effects by ingestion: ferthty effects. Experimental reproductive effects. Human mutation data reported. A steroid hormone much used in medicine. When heated to decomposition it emits acrid smoke and irritating fumes.
[Hazardous Substances Data]

50-28-2(Hazardous Substances Data)
Raw materials And Preparation ProductsBack Directory
[Raw materials]

Nitrogen-->p-Toluenesulfonic acid-->Litium-->Potassium borohydride-->Biphenyl-->Acetylacetone-->1,3,5(10)-Estratrien-3-ol-17-one-->Diphenylmethane-->4-ETHYL-2-METHYLPYRIDINE-->ADD
Material Safety Data Sheet(MSDS)Back Directory
[msds information]

1,3,5-Estratriene-3,17beta-diol(50-28-2).msds
Questions And AnswerBack Directory
[Indications and Usage]

Estradiol is a white or milky white ordorless crystalline powder. It is soluble in dioxane and acetone, slightly soluble in ethanol, and insoluble in water.
Estradiol is the intermediate between estradiol valerate and estradiol benzoate, and it is a type of estrogen drug. It can be used to treat uterine functional bleeding, primary amenorrhea, menopausal syndrome, and prostate cancer. Estradiol can promote and adjust the normal growth of female sex organs and secondary sex characteristics, promote mammary duct maturation and growth, and aid in posseting. Estradiol can also be used in biochemical research.
[Adverse reactions]

In high dosages, estradiol can inhibit the release of anterior pituitary prolactin, thus decreasing breast milk secretion. However, nausea, vomiting and endometrial hyperplasia-induced bleeding may occur. Patients with liver or kidney failure should use with caution.
[Contradictions]

Do not use on breasts, vaginal area and vaginal mucosa.
Spectrum DetailBack Directory
[Spectrum Detail]

Estradiol(50-28-2)IR1
Estradiol(50-28-2)IR2
Well-known Reagent Company Product InformationBack Directory
[Alfa Aesar]

beta-Estradiol, 99% (dry wt.), ca 3% water(50-28-2)
[Sigma Aldrich]

50-28-2(sigmaaldrich)
50-28-2 suppliers list
Company Name: Hubei XinRunde Chemical Co., Ltd.
Tel: +8615102730682; +8618874586545
Fax: 02783214688
Website: www.xrdchem.guidechem.com
Company Name: Meihua Biological Technology Co.,Ltd
Tel: 15175972705
Fax: 031145896235
Website: www.chemicalbook.com/ShowSupplierProductsList30679/0_EN.htm
Company Name: Biochempartner
Tel: 0086-13720134139
Fax:
Website: www.biochempartner.com
Company Name: Jinan Jianfeng Chemical Co., Ltd
Tel: 15562555968
Fax:
Website: www.chemicalbook.com/ShowSupplierProductsList31185/0.htm
Company Name: Xiamen AmoyChem Co., Ltd
Tel: +86 (0)592-605 1114
Fax:
Website: www.amoychem.com
Company Name: Hubei Jusheng Technology Co.,Ltd.
Tel: 86-188-71490254
Fax:
Website: www.chemicalbook.com/ShowSupplierProductsList31316/0.htm
Company Name: Hebei Guanlang Biotechnology Co., Ltd.
Tel: +8619930501651
Fax:
Website: www.chemicalbook.com/ShowSupplierProductsList31448/0.htm
Company Name: Hebei Chisure Biotechnology Co., Ltd.
Tel: +8613292893290
Fax: +8613292893290
Website: www.chemicalbook.com/ShowSupplierProductsList30840/0.htm
Company Name: Hebei Huanhao Biotechnology Co., Ltd.
Tel: 86-0311-83975816 whatsapp +8618034554576
Fax: 86-0311-83975816
Website: www.chemicalbook.com
Company Name: Henan DaKen Chemical CO.,LTD.
Tel: +86-371-55531817
Fax:
Website: www.dakentech.com
Company Name: career henan chemical co
Tel: +86-371-86658258
Fax:
Website: www.coreychem.com
Company Name: Hebei Guanlang Biotechnology Co., Ltd.
Tel: +86-0311-66562153 whatsapp +8615203118427
Fax: +86-0311-66562153
Website: www.chemicalbook.com/ShowSupplierProductsList30475/0_EN.htm
Company Name: Mainchem Co., Ltd.
Tel: +86-0592-6210733
Fax: +86-0592-6210733
Website: www.mainchem.com
Company Name: Nanjing Finetech Chemical Co., Ltd.
Tel: 025-85710122 17714198479
Fax: 025-85710122
Website: www.fine-chemtech.com
Company Name: Rixing Chemical CO.,LTD
Tel: 13237129059
Fax: -
Website: www.rixingchemi.com
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: 0371-55170693
Fax: 0371-55170693
Website: www.tianfuchem.net
Company Name: Hebei Jiangkai Trading Co., Ltd
Tel: 0086-17197824289/17197824028
Fax:
Website: www.hbjkai.com
Company Name: Changzhou Rongchuang Biotechnology Co., ltd.
Tel: 0519-83991290 18115001290
Fax: 0519-83991290
Website: www.chemicalbook.com/ShowSupplierProductsList30483/0_EN.htm
Tags:50-28-2 Related Product Information
50-23-7 87-89-8 632-69-9 313-06-4 152-43-2 50-27-1 57-63-6 72-33-3 4956-37-0 50-28-2 57-91-0 979-32-8 50-50-0