15579-01-8

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15579-01-8 Structure

Identification	Back Directory
[Name] Aminoethyl-SS-ethylalcohol
[CAS] 15579-01-8
[Synonyms] Aminoethyl-SS-ethylalcohol 2-[(2-Aminoethyl)disulfanyl]ethan-1-ol
[Molecular Formula] C4H11NOS2
[MDL Number] MFCD20694662
[MOL File] 15579-01-8.mol
[Molecular Weight] 153.27

Hazard Information	Back Directory
[Description] Aminoethyl-SS-ethylalcohol contains a primary amine group, a cleavable disulfide bond and a hydroxyl group. The amine group can be further reacted with carboxylic acids, activated NHS esters and other carbonyl groups. The alcohol group allows for further derivatization of the compound. The disulfide bond can be cleaved under reduction condition.
[Uses] Aminoethyl-SS-ethylalcohol is a glutathione cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
[IC 50] Disulfide Cleavable Linker; Cleavable Linker
[References] [1] Yuelog Ma, et al. HUMANIZED LEWIS-Y SPECIFIC ANTIBODY-BASED DELIVERY OF DICER SUBSTRATE siRNA (D-siRNA) AGAINST STAT3. US20130052731A1.

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