| Identification | Back Directory | [Name]
1H-Pyrano[3,4-b]benzofuran-3-acetamide, 6-(dimethylamino)-3,4,4a,9a-tetrahydro-1-(hydroxymethyl)-N-[(4-phenoxyphenyl)methyl]-, (1S,3S,4aS,9aR)- | [CAS]
1565827-99-7 | [Synonyms]
BRD0418
1H-Pyrano[3,4-b]benzofuran-3-acetamide, 6-(dimethylamino)-3,4,4a,9a-tetrahydro-1-(hydroxymethyl)-N-[(4-phenoxyphenyl)methyl]-, (1S,3S,4aS,9aR)- | [Molecular Formula]
C29H32N2O5 | [MOL File]
1565827-99-7.mol | [Molecular Weight]
488.57 |
| Chemical Properties | Back Directory | [Boiling point ]
718.7±60.0 °C(Predicted) | [density ]
1.220±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
14.22±0.10(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Description]
BRD0418 is an upregulator of TRIB1 expression. It acts by leading to the reprogramming of hepatic lipoprotein metabolism from lipogenesis to scavenging. | [Uses]
BRD0418 is a diversity-oriented synthesis (DOS) molecule that regulates the expression of tribbles pseudokinase 1. BRD0418 has the effect of causing hot lipoprotein metabolism from fat production to clearance. BRD0418 can be used in the study of coronary artery disease (CAD) [1]. | [Definition]
ChEBI: 2-[(1S,3S,4aS,9aR)-6-(dimethylamino)-1-(hydroxymethyl)-3,4,4a,9a-tetrahydro-1H-pyrano[3,4-b]benzofuran-3-yl]-N-[(4-phenoxyphenyl)methyl]acetamide is an aromatic ether. | [References]
[1] Nagiec MM, et al. Modulators of hepatic lipoprotein metabolism identified in a search for small-molecule inducers of tribbles pseudokinase 1 expression. PLoS One. 2015 Mar 26;10(3):e0120295. DOI:10.1371/journal.pone.0120295 |
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