| Identification | Back Directory | [Name]
6-chlorophenanthridine | [CAS]
15679-03-5 | [Synonyms]
MFCD01628084
6-chlorophenidine
6-chlorophenanthridine
Phenanthridine,6-chloro-
6-Chlorophenanthridine 95+% | [Molecular Formula]
C13H8ClN | [MDL Number]
MFCD01628084 | [MOL File]
15679-03-5.mol | [Molecular Weight]
213.66 |
| Chemical Properties | Back Directory | [Melting point ]
117-118 °C | [Boiling point ]
377.7±15.0 °C(Predicted) | [density ]
1.312±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,2-8°C | [form ]
solid | [pka]
2.36±0.40(Predicted) | [color ]
Light beige | [InChI]
InChI=1S/C13H8ClN/c14-13-11-7-2-1-5-9(11)10-6-3-4-8-12(10)15-13/h1-8H | [InChIKey]
XHZTZKAXCPJABO-UHFFFAOYSA-N | [SMILES]
C1C2C(=NC(Cl)=C3C=2C=CC=C3)C=CC=1 |
| Hazard Information | Back Directory | [Synthesis]
General procedure for the synthesis of 6-chlorophenanthridine from 6(5H)-phenanthridone: Phosphoryl chloride (15 mL) and dimethylaniline (0.63 mL) were sequentially added to a reaction flask containing phenanthridine (2.0 g), followed by heating and refluxing for 3 hours. Upon completion of the reaction, the reaction solution was slowly poured into water and the solid product was precipitated. The solid was extracted with chloroform and the combined organic phases were dried over anhydrous sodium sulfate. The desiccant was removed by filtration and the filtrate was concentrated to dryness under reduced pressure. The resulting crude product was purified by column chromatography (eluent: chloroform) to afford the target compound 6-chlorophenanthridine (2.1 g, yield: 96%).1H NMR (300 MHz, CDCl3, TMS, room temperature): δ 8.63-8.60 (1H, d), 8.55-8.52 (1H, d), 8.50-8.48 (1H, d), 8.11-8.09 (1H, d). 8.09 (1H, d), 7.94-7.92 (1H, t), 7.79-7.66 (3H, m). | [References]
[1] Patent: US2011/201802, 2011, A1. Location in patent: Page/Page column 10
[2] Patent: US9281483, 2016, B2. Location in patent: Page/Page column 83
[3] Patent: KR2016/30582, 2016, A. Location in patent: Paragraph 0162; 0163; 0164; 0165; 0166
[4] Dalton Transactions, 2014, vol. 43, # 44, p. 16872 - 16879
[5] Patent: CN105949246, 2016, A. Location in patent: Paragraph 0025; 0044-0046; 0049 |
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