| Identification | Back Directory | [Name]
Datelliptium chloride hydrochloride | [CAS]
157000-76-5 | [Synonyms]
Datelliptium chloride hydrochloride | [Molecular Formula]
C23H28ClN3O | [MDL Number]
MFCD01749605 | [MOL File]
157000-76-5.mol | [Molecular Weight]
397.95 |
| Hazard Information | Back Directory | [Uses]
Datelliptium chloride hydrochloride is a DNA-intercalating agent derived from Ellipticine (HY-15753). Datelliptium chloride hydrochloride is effective in vivo against a variety of murine solid tumors[1][2]. | [in vivo]
Datelliptium chloride hydrochloride has broad antitumor activity against solid tumors of mice in vivo[2].
Datelliptium chloride hydrochloride (170 mg/kg; i.v; for 12 days) exhibits a high degree of antitumor activity at early staged disease[2].
Datelliptium chloride hydrochloride is selectively cytotoxic for solid tumors over leukemia L1210[2].
| Animal Model: | Mice, colon adenocarcinoma early staged disease model[2] | | Dosage: | 170 mg/kg | | Administration: | Intravenous injection, for 12 days | | Result: | Showed potent activity against colon adenocarcinoma. |
| [References]
[1] Donato MT, et al. Toxicity of the antitumoral drug datelliptium in hepatic cells: Use of models in vitro for the prediction of toxicity in vivo. Toxicol In Vitro. 1992 Jul;6(4):295-302. DOI:10.1016/0887-2333(92)90019-n
[2] Mucci-LoRusso P, et al. Activity of datelliptium acetate (NSC 311152; SR 95156A) against solid tumors of mice. Invest New Drugs. 1990 Aug;8(3):253-61. DOI:10.1007/BF00171834 |
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