157000-76-5
中文名称
化合物T7747
英文名称
Datelliptium chloride hydrochloride
CAS
157000-76-5
分子式
C23H28ClN3O
分子量
397.95
MOL 文件
157000-76-5.mol
157000-76-5 结构式
基本信息
中文别名
化合物T7747化合物 DATELLIPTIUM CHLORIDE HYDROCHLORIDE
英文别名
Datelliptium chloride hydrochlorideantitumoral,Datelliptium chloride hydrochloride,DNA/RNA Synthesis,activity,Inhibitor,Ellipticine,hepatotoxicity,inhibit,Datelliptium chloride,antineoplastic
物理化学性质
溶解度DMSO: Sparingly soluble: 1-10 mg/ml
Ethanol: Soluble: = 10 mg/mlPBS (pH 7.2): Sparingly soluble: 1-10 mg/ml
Ethanol: Soluble: = 10 mg/mlPBS (pH 7.2): Sparingly soluble: 1-10 mg/ml
常见问题列表
生物活性
Datelliptium chloride hydrochloride 是一种由 Ellipticine (HY-15753) 衍生的 DNA 嵌合剂。Datelliptium chloride hydrochloride 在体内对多种小鼠实体瘤有效。体外研究
Datelliptium chloride hydrochloride shows cytotoxic effects after 2 hours of treatment in suspension and primary cultures of rat hepatocytes.
体内研究
Datelliptium chloride hydrochloride has broad antitumor activity against solid tumors of mice in vivo.
Datelliptium chloride hydrochloride (170 mg/kg; i.v; for 12 days) exhibits a high degree of antitumor activity at early staged disease.
Datelliptium chloride hydrochloride is selectively cytotoxic for solid tumors over leukemia L1210.
| Animal Model: | Mice, colon adenocarcinoma early staged disease model |
| Dosage: | 170 mg/kg |
| Administration: | Intravenous injection, for 12 days |
| Result: | Highly active against colon adenocarcinoma. |