| Identification | Back Directory | [Name]
2-((3,5-DI-TERT-BUTYL-4-HYDROXYPHENYL)-METHYLENE)-4-CYCLOPENTENE-1,3-DIONE | [CAS]
157397-06-3 | [Synonyms]
TX-1123
TX-1123 - CAS 157397-06-3 - Calbiochem
2-((3,5-DI-TERT-BUTYL-4-HYDROXYPHENYL)-METHYLENE)-4-CYCLOPENTENE-1,3-DIONE | [Molecular Formula]
C20H24O3 | [MDL Number]
MFCD06411461 | [MOL File]
157397-06-3.mol | [Molecular Weight]
312.4 |
| Chemical Properties | Back Directory | [Boiling point ]
442.4±44.0 °C(Predicted) | [density ]
1.137±0.06 g/cm3(Predicted) | [storage temp. ]
+2C to +8C | [solubility ]
Soluble in DMSO (10mg/ml) | [form ]
Yellow solid | [pka]
10.04±0.50(Predicted) | [color ]
yellow | [InChI]
1S/C20H24O3/c1-19(2,3)14-10-12(9-13-16(21)7-8-17(13)22)11-15(18(14)23)20(4,5)6/h7-11,23H,1-6H3 | [InChIKey]
VUEUMQIBGLKJJD-UHFFFAOYSA-N | [SMILES]
Oc1c(cc(cc1C(C)(C)C)C=C2C(=O)C=CC2=O)C(C)(C)C |
| Hazard Information | Back Directory | [Uses]
TX-1123 is a protein tyrosine kinase inhibitor, having low mitochondrial toxicity and antitumor activity. | [Biological Activity]
Cell permeable: yes''Primary Target
Src''Product competes with ATP.''Reversible: yes''Target IC50: 2.23.2and 9.6 μM against SrceEF2-Kand PKArespectively | [IC 50]
COX-2: 1.16 nM (IC50); COX-1: 15.7 μM (IC50) | [storage]
+4°C |
|
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
Merck Millipore
|
| Tel: |
1-400-889-1988 400-889-1988 |
| Website: |
http://www.merckmillipore.com |
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
|