| Identification | Back Directory | [Name]
Ethyl (hydroxyimino)cyanoacetate potassium salt | [CAS]
158014-03-0 | [Synonyms]
K-Oxyma
K-Oxyma 97%
K-Oxyma Pure
K-OXYMA PURE 25 G
K-Oxyma≥ 99% (HPLC)
OxymaPurepotassiumsalt
K-Oxyma Pure Novabiochem
Ethyl (hydroxyimino)cyanoacetate potassium
Ethyl (hydroxyimino)cyanoacetate potassium salt
Ethyl 2-cyano-2-(hydroxyimino)acetate, potassium salt
Cyano(hydroxyimino)acetic acid ethyl ester potassium salt
Cyano-2-(hydroxyimino)acetic acid ethyl ester potassium salt
2-Cyano-2-(hydroxyimino)acetic acid ethyl ester, potassium salt
2-Cyano-2-(hydroxyimino)acetic acid ethyl ester potassium salt (1:1)
2-Cyano-2-(hydroxyimino)acetic Acid Ethyl Ester Potassium Salt (K-OXYMA) | [Molecular Formula]
C5H5KN2O3 | [MDL Number]
MFCD26960809 | [MOL File]
158014-03-0.mol | [Molecular Weight]
180.203 |
| Chemical Properties | Back Directory | [Melting point ]
145-155°C | [storage temp. ]
2-8°C | [solubility ]
Methanol (Slightly), Water (Sparingly) | [form ]
Solid | [color ]
Dark Yellow | [InChI]
InChI=1S/C5H6N2O3.K/c1-2-10-5(8)4(3-6)7-9;/h9H,2H2,1H3;/q;+1/p-1/b7-4+; | [InChIKey]
ZFBMUWGNRJITLS-KQGICBIGSA-M | [SMILES]
[K+].C(OCC)(=O)/C(=N/[O-])/C#N |
| Hazard Information | Back Directory | [Chemical Properties]
Bright yellow powder | [Uses]
- Non-explosive replacement for HOBt and HOAt with at least comparable performance to HOAt
- Outperforms HOAt in sterically demanding peptide bond formations
- Compatible with carbodiimide-mediated; solution and solid phase peptide coupling;
- Less epimerization than HOBt in fragment condensation reactions
- K-salt especially useful in peptide coupling on mild acid-labile resins such as 2-chlorotrityl; leading to minimal to no cleavage of the peptide from the resin due to its more alkaline character
- K-salt has a higher melting point than OxymaPure
| [Uses]
Ethyl (hydroxyimino)cyanoacetate potassium salt is a Non-explosive replacement for HOBt and HOAt with at least comparable performance to HOAt Outperforms HOAt in sterically demanding peptide bond formations Compatible with carbodiimide-mediated; solution and solid phase peptide coupling; Less epimerization than HOBt in fragment condensation reactions K-salt especially useful in peptide coupling on mild acid-labile resins such as 2-chlorotrityl; leading to minimal to no cleavage of the peptide from the resin due to its more alkaline character K-salt has a higher melting point than OxymaPure. | [Uses]
Useful in peptide coupling on mild acid-labile resins with minimal to no cleavage of the peptide from the resin due to its more alkaline character. This can be used to replace the explosive HOBt and HOAt. | [reaction suitability]
reaction type: Coupling Reactions |
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Sigma-Aldrich
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https://www.sigmaaldrich.cn |
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