| Identification | Back Directory | [Name]
Catalpalactone | [CAS]
1585-68-8 | [Synonyms]
Catalpalactone
1(3H)-Isobenzofuranone,3-(5,6-dihydro-6,6-dimethyl-2-oxo-2H-pyran-3-yl)- | [Molecular Formula]
C15H14O4 | [MDL Number]
MFCD20261010 | [MOL File]
1585-68-8.mol | [Molecular Weight]
258.27 |
| Chemical Properties | Back Directory | [Melting point ]
110-111 °C | [Boiling point ]
467.1±45.0 °C(Predicted) | [density ]
1.269±0.06 g/cm3(Predicted) | [solubility ]
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | [form ]
Powder | [LogP]
2.050 (est) |
| Hazard Information | Back Directory | [Uses]
Catalpalactone has anti-inflammatory effect. Catalpalactone inhibits LPS-induced NO production and iNOS expression in RAW264.7 cells, and also inhibits IRF3, NF-κB, and IFN-β/STAT-1 activation. Catalpalactone also inhibits dopamine biosynthesis by reducing tyrosine hydroxylase (TH) and aromatic-l-amino acid decarboxylase (AADC) activities[1][2]. | [Definition]
ChEBI: Catalpalactone is a member of 2-benzofurans. | [target]
cAMP | NO | [References]
[1] Kim HY, et al. Anti-Inflammatory Effects of Catalpalactone Isolated from Catalpa ovata in LPS-Induced RAW264.7 Cells. Molecules. 2019 Mar 29;24(7):1236. DOI:10.3390/molecules24071236
[2] Huang HS, et al. Effects of catalpalactone on dopamine biosynthesis and L-DOPA-induced cytotoxicity in PC12 cells. Environ Toxicol Pharmacol. 2008 Jul;26(1):86-91. DOI:10.1016/j.etap.2008.02.005 |
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