| Identification | Back Directory | [Name]
a-Helical Corticotropin Releasing Factor (12-41) | [CAS]
158535-55-8 | [Synonyms]
α-Helical CRF (12-41)
a-Helical CRF (12-41)
PubChem ID: 131849100
α-Helical CRF (12-41)
ALFA-HELICAL CRF (12-41)
12-41-Corticotropin-releasing factor(human)
α-Helical CRF (12-41) trifluoroacetate salt
a-Helical Corticotropin Releasing Factor (12-41)
PHE-HIS-LEU-LEU-ARG-GLU-MET-LEU-GLU-MET-ALA-LYS-ALA-GLU-GLN-GLU-ALA-GLU-GLN-ALA-ALA-LEU-ASN-ARG-LEU-LEU-LEU-GLU-GLU-ALA-NH2
H-Phe-His-Leu-Leu-Arg-Glu-Met-Leu-Glu-Met-Ala-Lys-Ala-Glu-Gln-Glu-Ala-Glu-Gln-Ala-Ala-Leu-Asn-Arg-Leu-Leu-Leu-Glu-Glu-Ala-NH2
L-Alaninamide, L-phenylalanyl-L-histidyl-L-leucyl-L-leucyl-L-arginyl-L-α-glutamyl-L-methionyl-L-leucyl-L-α-glutamyl-L-methionyl-L-alanyl-L-lysyl-L-alanyl-L-α-glutamyl-L-glutaminyl-L-α-glutamyl-L-alanyl-L-α-glutamyl-L-glutaminyl-L-alanyl-L-alanyl-L-leucyl-L-asparaginyl-L-arginyl-L-leucyl-L-leucyl-L-l... | [Molecular Formula]
C152H251N43O47S2 | [MDL Number]
MFCD00214568 | [MOL File]
158535-55-8.mol | [Molecular Weight]
3497.01 |
| Hazard Information | Back Directory | [Uses]
a-Helical Corticotropin Releasing Factor (12-41) is a 30 amino acids long, α-helical analogue of corticotropin releasing factor/hormone. Corticotropin releasing factor (CRF) is a hypothalamic hormone, which stimulates the secretion of adrenocorticotrophic hormone (ACTH). a-Helical Corticotropin Releasing Factor (12-41) would suppress the stimulatory effect[1][2]. | [in vivo]
a-Helical Corticotropin Releasing Factor (12-41) (15-150 μg; s.c.; isolated for 30 or 60 min) suppresses the active behavioral response characteristic of guinea pig pups to brief isolation in novel surroundings[1].
| Animal Model: | Guinea pig pups (20-26 days old and )[1] | | Dosage: | 15, 50, 150 μg per animal | | Administration: | Subcutaneous injection; isolated in novel surroundings for 30 min or 60 min. | | Result: | Resulted pups vocalized more and exhibited more locomotor activity in 20- to 26-day-old pups.
Increased levels of vocalizing in isolated 4- to 6-day-old pups at 50 μg dose, though no changes were seen in locomotor activity. |
| [References]
[1] Hennessy MB, et al. Evidence that endogenous corticotropin-releasing factor suppresses behavioral responses of guinea pig pups to brief isolation in novel surroundings. Dev Psychobiol. 1997 Jul;31(1):39-47. DOI:10.1002/(sici)1098-2302(199707)31:1<39::aid-dev4>3.0.co;2-v
[2] Ellis M J, et al. The effects of corticotrophin-releasing hormone, arginine vasopressin and their antagonists on ACTH release from perifused horse anterior pituitary cells[J]. Journal of endocrinology, 1994, 143(1): 85-93. |
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