| Identification | Back Directory | [Name]
2-(1-Phenyl-cyclopropylamino)-pyrimidine-5-carboxylic acid ethyl ester | [CAS]
1598426-03-9 | [Synonyms]
CG347B
CTTSUGRYXUPYIO-UHFFFAOYSA-N
2-(1-Phenyl-cyclopropylamino)-pyrimidine-5-carboxylic acid ethyl ester
5-Pyrimidinecarboxylic acid, 2-[(1-phenylcyclopropyl)amino]-, ethyl ester | [Molecular Formula]
C16H17N3O2 | [MDL Number]
MFCD28347705 | [MOL File]
1598426-03-9.mol | [Molecular Weight]
283.33 |
| Chemical Properties | Back Directory | [Boiling point ]
457.2±47.0 °C(Predicted) | [density ]
1.278±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 250 mg/mL (882.36 mM) | [form ]
Solid | [pka]
1.94±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
CG347B is a selective HDAC6 inhibitor, also involves in synthesis of other metalloenzyme inhibitors. HDAC6 inhibitors can be used for oncology, immunology, and neurology research[1][2]. | [IC 50]
HDAC6 | [References]
[1] Wang W, et al. Characterization of a novel HDAC/RXR/HtrA1 signaling axis as a novel target to overcome cisplatin resistance in human non-small cell lung cancer. Mol Cancer. 2020 Sep 2;19(1):134. DOI:10.1186/s12943-020-01256-9
[2] Christopher M. YATES. Metalloenzyme inhibitor compounds. WO2018165520A1.
[3] Cui J, et al. IL-4 inhibits regulatory T cells differentiation by HDAC9-mediated epigenetic regulation. Cell Death Dis. 2021 May 18;12(6):501. DOI:10.1038/s41419-021-03769-7 |
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BOC Sciences
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1-631-485-4226; 16314854226 |
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https://www.bocsci.com |
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