| Identification | Back Directory | [Name]
Auristatin E | [CAS]
160800-57-7 | [Synonyms]
Auristatin E
L-Valinamide, N,N-dimethyl-L-valyl-N-[(1S,2R)-4-[(2S)-2-[(1R,2R)-3-[[(1R,2S)-2-hydroxy-1-methyl-2-phenylethyl]amino]-1-methoxy-2-methyl-3-oxopropyl]-1-pyrrolidinyl]-2-methoxy-1-[(1S)-1-methylpropyl]-4-oxobutyl]-N-methyl- | [Molecular Formula]
C40H69N5O7 | [MDL Number]
MFCD25976744 | [MOL File]
160800-57-7.mol | [Molecular Weight]
732.01 |
| Chemical Properties | Back Directory | [Melting point ]
92-94 °C | [Boiling point ]
871.0±65.0 °C(Predicted) | [density ]
1.085±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C,unstable in solution, ready to use. | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
13.66±0.20(Predicted) | [color ]
White to light yellow | [InChIKey]
MOBSAMWSCWMKOB-FEFUEGSOSA-N | [SMILES]
C(NC(=O)[C@H](C(C)C)N(C)C)(=O)[C@H](C(C)C)N([C@@H]([C@@H](C)CC)[C@H](OC)CC(N1CCC[C@H]1[C@H](OC)[C@@H](C)C(N[C@H](C)[C@@H](O)C1=CC=CC=C1)=O)=O)C |
| Hazard Information | Back Directory | [Description]
Auristatin E is a cytotoxic tubulin modifier with potent and selective antitumor activity; it is a synthetic analog of dolastatin 10. Auristatin E is a highly potent antimitotic agent. Auristatin E inhibits tubulin polymerization(1). Auristatin E-antibody cunjugates have proven to be successful anticancer agents.(2)
Ref. 1. Pettit et al. Anticancer Drug Des. 1995 10:529.
Ref. 2. Doronina et al. Nature Biotechnol. 2003 21:778. | [Uses]
Auristatin E (GMP) is Auristatin E (HY-15582) produced by using GMP guidelines. Auristatin E is a tubulin polymerization inhibitor[1]. | [storage]
Store at -20°C,unstable in solution, ready to use. | [References]
[1] Francisco JA, et al. cAC10-vcMMAE, an anti-CD30-monomethyl auristatin E conjugate with potent and selective antitumor activity. Blood. 2003 Aug 15;102(4):1458-65. DOI:10.1182/blood-2003-01-0039 |
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