| Identification | Back Directory | [Name]
Silodosin | [CAS]
160970-64-9 | [Synonyms]
Silodosin RS
rac-Silodosin
Silodosin Racemate
high quality Silodosin
Silodosin, racemic mixture
Silodosin Impurity 19 (rac-Silodosin)
Silodosin sodium salt, racemic mixture
1-(3-hydroxypropyl)-5-(2-((2-(2-(2,2,2-trifluoroethoxy)phenoxy)ethyl)amino)propyl)indoline-7-carboxamide
1-(3-Hydroxypropyl)-5-[(2R)-2-({2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl}amino)propyl]-7-indolinecarboxamide
2,3-Dihydro-1-(3-hydroxypropyl)-5-[2-[[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl]amino]propyl]-1H-indole-7-carboxamide
1H-Indole-7-carboxamide, 2,3-dihydro-1-(3-hydroxypropyl)-5-[2-[[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl]amino]propyl]-
1-(3-Hydroxy-propyl)-5-(2(R)-{2-[2-(2,2,2-trifluoro-ethoxy)-phenoxy]-ethylamino}-propyl)-2,3-dihydro-1H-indol-7-carboxylic acid amide | [EINECS(EC#)]
1806240-263-5 | [Molecular Formula]
C25H32F3N3O4 | [MOL File]
160970-64-9.mol | [Molecular Weight]
495.53 |
| Hazard Information | Back Directory | [Description]
Silodosin is an alpha-1 adrenergic receptor antagonist used to treat benign prostatic hyperplasia (BPH) symptoms. It is used in men to treat the symptoms of an enlarged prostate (benign prostatic hyperplasia; BPH), which include difficulty urinating (hesitation, dribbling, weak stream, and incomplete bladder emptying), painful urination, and urinary frequency and urgency. It relieves the symptoms of BPH by relaxing the muscles of the bladder and prostate.
| [Uses]
(Rac)-Silodosin ((Rac)-KAD 3213) is the racemate of Silodosin (HY-10122). Silodosin is a potent, selective and orally active α1A-adrenergic receptor (α1A-AR) blocker[1]. | [References]
[1] Zhao F, et, al. Design, Synthesis, and Biological Evaluation of Indoline and Indole Derivatives as Potent and Selective α1A-Adrenoceptor Antagonists. J Med Chem. 2016 Apr 28;59(8):3826-39. DOI:10.1021/acs.jmedchem.5b02023 |
|
|