| Identification | More | [Name]
2-AMINO-5-METHYLBENZAMIDE | [CAS]
40545-33-3 | [Synonyms]
2-AMINO-5-METHYLBENZAMIDE
Benzamide, 2-amino-5-methyl-(9CI)
Benzamide, 2-amino-5-methyl- | [Molecular Formula]
C8H10N2O | [MDL Number]
MFCD03428521 | [Molecular Weight]
150.18 | [MOL File]
40545-33-3.mol |
| Chemical Properties | Back Directory | [Melting point ]
178-180°C | [Boiling point ]
265.7±28.0 °C(Predicted) | [density ]
1.185±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [form ]
solid | [pka]
15.88±0.50(Predicted) | [Appearance]
Off-white to light yellow Solid | [InChI]
1S/C8H10N2O/c1-5-2-3-7(9)6(4-5)8(10)11/h2-4H,9H2,1H3,(H2,10,11) | [InChIKey]
LLSGVPKOCZZLTF-UHFFFAOYSA-N | [SMILES]
Cc1ccc(N)c(c1)C(N)=O | [CAS DataBase Reference]
40545-33-3(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Synthesis]
Step 2: 5-Methyl-2-nitrobenzamide (15.0 g, 83.3 mmol) was dissolved in methanol (300 mL) and 10% palladium carbon catalyst (2.50 g) was added. The reaction was stirred for 12 hours under hydrogen atmosphere (1 atmosphere) and room temperature. After completion of the reaction, the insoluble material was removed by filtration and the filtrate was concentrated to afford 2-amino-5-methylbenzamide (12.4 g, 99% yield) in white powder form. | [References]
[1] Patent: EP1953148, 2008, A1. Location in patent: Page/Page column 130
[2] Patent: US2015/329556, 2015, A1. Location in patent: Paragraph 1532
[3] Journal of Medicinal Chemistry, 1992, vol. 35, # 14, p. 2626 - 2630
[4] Patent: US5234925, 1993, A
[5] European Journal of Medicinal Chemistry, 2011, vol. 46, # 7, p. 2786 - 2796 |
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