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Deltarasin hydrochloride is an inhibitor of?KRAS-PDEδinteraction with?Kd?of 38 nM for binding to purified PDEδ. | [in vivo]
Deltarasin (10 mg/kg, i.p.) impairs dose-dependent tumor growth in nude mice bearing subcutaneous human Panc-Tu-I tumour cell xenografts[1]. | [References]
[1] Zimmermann G, et al. Small molecule inhibition of the KRAS-PDEδ interaction impairs oncogenic KRAS signalling. Nature. 2013 May 30;497(7451):638-42. DOI:10.1038/nature12205 |
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