| Identification | Back Directory | [Name]
[(3S,4aS,6aR,6bS,8aR,12aR,14aS,14bS)-4,4,6a,6b,8a,11,11,14b-octamethyl -1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicen-3-yl] acetate | [CAS]
1616-93-9 | [Synonyms]
β-Amyrin acetate
O-Acetyl-β-amyrin
β-Amyrenyl acetate
beta-Amyrin acetate
Erythrodiol 3-acetate
Olean-12-en-3β-ol acetate
AMYRIN ACETATE, BETA- (RG)
Olean-12-en-3-ol,3-acetate, (3b)-
Acetic acid 5α-olean-12-en-3β-yl ester
(4,4,6a,6b,8a,11,11,14b-octamethyl-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicen-3-yl)acetate
[(3S,4aS,6aR,6bS,8aR,12aR,14aS,14bS)-4,4,6a,6b,8a,11,11,14b-octamethyl -1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicen-3-yl] acetate | [EINECS(EC#)]
200-258-5 | [Molecular Formula]
C32H52O2 | [MDL Number]
MFCD00200955 | [MOL File]
1616-93-9.mol | [Molecular Weight]
468.75 |
| Chemical Properties | Back Directory | [solubility ]
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | [form ]
Powder | [color ]
White to off-white | [LogP]
11.950 (est) |
| Hazard Information | Back Directory | [Uses]
β-Amyrin acetate is a triterpenoid with potent anti-inflammatory, antifungal, anti-diabetic, anti-hyperlipidemic activities. β-Amyrin acetate can inhibit HMG-CoA reductase activity by locating in the hydrophobic binding cleft of HMG CoA reductase[1][2][3][4]. | [in vivo]
β-Amyrin acetate (applied on the anterior surface of the right ear, 100 μg/ear, a single dose) significantly inhibits xylene-induced ear edema in mice[1].
β-Amyrin acetate (intraperitoneal injection, 4 mg/100 g, daily for 6 consecutive days) shows significant anti-inflammatory activities (43.6%) in adult albino rats[3].
β-Amyrin acetate (subcutaneous injection, 4 mg/100 g, daily for 10 days ) increases the ATP-phosphohydrolase activity in liver homogenates both in normal and arthritic rats[3]. | Animal Model: | Xylene-induced mouse ear topical edema model[1] | | Dosage: | 50 and 100 μg/ear (5 μL) | | Administration: | Applied on the anterior surface of the right ear | | Result: | Inhibited Xylene-induced ear edema in mice |
| Animal Model: | Adult albino rats[3] | | Dosage: | 4 mg/100g, daily for 6 consecutive days | | Administration: | Intraperitoneal injection | | Result: | Showed significant anti-inflammatory activities with mean average weight of granulation tissue of 9.2 mg after 6 days. |
| [target]
Immunology & Inflammation related | [References]
[1] Nkeoma Nkasi Okoye, et al. beta-Amyrin and alpha-amyrin acetate isolated from the stem bark of Alstonia boonei display profound anti-inflammatory activity. Pharm Biol. 2014 Nov;52(11):1478-86. DOI:10.3109/13880209.2014.898078
[2] Ranjani Maurya, et al. β-Amyrin acetate and β-amyrin palmitate as antidyslipidemic agents from Wrightia tomentosa leaves. Phytomedicine. 2012 Jun 15;19(8-9):682-5. DOI:10.1016/j.phymed.2012.03.013
[3] M.B.Gupta, et al. Biochemical study of the anti-inflammatory activity of α and β-amyrin acetate. Biochemical Pharmacology. 1971 Feb; 2(20): 401-405.
[4] S Johann, et al. Antifungal activity of the amyrin derivatives and in vitro inhibition of Candida albicans adhesion to human epithelial cells. Lett Appl Microbiol. 2007 Aug;45(2):148-53. DOI:10.1111/j.1472-765X.2007.02162.x |
| Spectrum Detail | Back Directory | [Spectrum Detail]
[(3S,4aS,6aR,6bS,8aR,12aR,14aS,14bS)-4,4,6a,6b,8a,11,11,14b-octamethyl -1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicen-3-yl] acetate(1616-93-9)MS
[(3S,4aS,6aR,6bS,8aR,12aR,14aS,14bS)-4,4,6a,6b,8a,11,11,14b-octamethyl -1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicen-3-yl] acetate(1616-93-9)1HNMR
[(3S,4aS,6aR,6bS,8aR,12aR,14aS,14bS)-4,4,6a,6b,8a,11,11,14b-octamethyl -1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicen-3-yl] acetate(1616-93-9)IR1
[(3S,4aS,6aR,6bS,8aR,12aR,14aS,14bS)-4,4,6a,6b,8a,11,11,14b-octamethyl -1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicen-3-yl] acetate(1616-93-9)IR2
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