| Identification | Back Directory | [Name]
CI 1020 | [CAS]
162256-50-0 | [Synonyms]
CI 1020
PD 156707
3-(1,3-Benzodioxol-5-yl)-5-hydroxy-5-(4-methoxyphenyl)-4-[(3,4,5-trimethoxyphenyl)methyl]-2(5H)-furanone
2(5H)-Furanone, 3-(1,3-benzodioxol-5-yl)-5-hydroxy-5-(4-methoxyphenyl)-4-[(3,4,5-trimethoxyphenyl)methyl]- | [Molecular Formula]
C28H26O9 | [MDL Number]
MFCD00867525 | [MOL File]
162256-50-0.mol | [Molecular Weight]
506.5 |
| Hazard Information | Back Directory | [Uses]
A novel endothelin-A receptor antagonist, in hypoxic pulmonary hypertension. | [Biological Activity]
Highly selective, orally active, non-peptide endothelin-A receptor (ET A ) antagonist (IC 50 values are 0.3 and 480 nM for ET A and ET B receptors respectively). Antihypertensive; blocks ET-1-induced pressor responses following oral administration. | [in vivo]
CI-1020 (30 mg/kg, p.o.) represents full inhibition of the ET-A and has no significant effect on basal blood pressure in normotensive rats[2].
CI-1020 (40 mg/kg, p.o.) attenuates established pulmonary hypertension in rats previously exposed to chronic hypoxia[4]. | Animal Model: | normal rats [2] | | Dosage: | 30 mg/kg | | Administration: | oral administration (p.o.) | | Result: | Inhibited the ET-A and has no significant effect on basal blood pressure in normotensive rats. |
| Animal Model: | basal blood pressure in normotensive rats[4] | | Dosage: | 40 mg/kg/day | | Administration: | oral administration (p.o.) | | Result: | Reduced the increase in RV/LV+S and the percentage DEL induced by chronic hypoxia.
Lowered the increase in pulmonary resistance in isolated perfused lungs significantly.
|
| [IC 50]
ETA: 0.3 nM (IC50) |
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| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
|