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API32 is a potent Pin1 inhibitor. API32 interactes with the Pin1 PPIase domain. API32 inhibits cell proliferation and migration. API32 has the potential for the research of hepatocellular carcinoma (HCC)[1]. | [References]
[1] Pu W, et al. Structure-Guided Optimization and Preclinical Evaluation of 6-O-Benzylguanine-Based Pin1 Inhibitor for Hepatocellular Carcinoma Treatment. J Med Chem. 2025 Feb 13;68(3):2869-2889. DOI:10.1021/acs.jmedchem.4c02144 |
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