ChemicalBook--->CAS DataBase List--->1628343-77-0

1628343-77-0

1628343-77-0 Structure

1628343-77-0 Structure
IdentificationBack Directory
[Name]

ARN 726 (ARN726)
[CAS]

1628343-77-0
[Synonyms]

ARN 726 (ARN726)
ARN726 4-Cyclohexylbutyl-N-[(S)-2-oxoazetidin-3-yl]-carbamate
Carbamic acid, N-[(3S)-2-oxo-3-azetidinyl]-, 4-cyclohexylbutyl ester
[Molecular Formula]

C14H24N2O3
[MOL File]

1628343-77-0.mol
[Molecular Weight]

268.35
Chemical PropertiesBack Directory
[Boiling point ]

478.8±34.0 °C(Predicted)
[density ]

1.12±0.1 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

DMF: 33 mg/ml; DMSO: 33 mg/ml; Ethanol: 33 mg/ml; Ethanol:PBS (pH 7.2) (1:4): 0.20 mg/ml
[form ]

A crystalline solid
[pka]

10.53±0.20(Predicted)
[color ]

White to off-white
Hazard InformationBack Directory
[Uses]

ARN726 is a potent NAAA (N-acylethanolamine acid amidase) inhibitor with an IC50 of 0.073 μM. ARN726 decreases alcohol self-administration in a dose-dependent manner[1][2].
[storage]

Store at -20°C
[References]

[1] Fotio Y, et al. N-acylethanolamine acid amidase (NAAA) inhibition decreases the motivation for alcohol in Marchigian Sardinian alcohol-preferring rats. Psychopharmacology (Berl). 2021 Jan;238(1):249-258. DOI:10.1007/s00213-020-05678-7
[2] Petracca R, et al. Novel activity-based probes for N-acylethanolamine acid amidase. Chem Commun (Camb). 2017 Aug 22;53(86):11810-11813. DOI:10.1039/c7cc06838g
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