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1628752-83-9

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1628752-83-9 Structure

1628752-83-9 Structure
IdentificationBack Directory
[Name]

Palbociclib-d8
[CAS]

1628752-83-9
[Synonyms]

PD 0332991-d8
Palbociclib-d8
[2H8]-Palbociclib
6-acetyl-8-cyclopentyl-5-methyl-2-((5-(piperazin-1-yl-2,2,3,3,5,5,6,6-d8)pyridin-2-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one
[Molecular Formula]

C24H21D8N7O2
[MDL Number]

MFCD33023239
[MOL File]

1628752-83-9.mol
[Molecular Weight]

455.582
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C
[solubility ]

DMSO: Soluble
[form ]

A solid
[color ]

Light yellow to yellow
Hazard InformationBack Directory
[Uses]

Palbociclib-d8 is labelled Palbociclib (P139900), an experimental drug for the treatment of breast cancer being developed by Pfizer. It is a selective inhibitor of the cyclin-dependent kinases CDK4 and CDK6.
[IC 50]

Cdk4/cyclin D3: 9 nM (IC50); Cdk4/cyclin D1: 11 nM (IC50); Cdk6/cyclin D2: 16 nM (IC50); DYRK1A: 2000 nM (IC50); MAPK: 8000 nM (IC50)
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