1628752-83-9

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1628752-83-9 Structure

Identification	Back Directory
[Name] Palbociclib-d8
[CAS] 1628752-83-9
[Synonyms] PD 0332991-d8 Palbociclib-d8 [2H8]-Palbociclib 6-acetyl-8-cyclopentyl-5-methyl-2-((5-(piperazin-1-yl-2,2,3,3,5,5,6,6-d8)pyridin-2-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one
[Molecular Formula] C24H21D8N7O2
[MDL Number] MFCD33023239
[MOL File] 1628752-83-9.mol
[Molecular Weight] 455.582

Hazard Information	Back Directory
[Uses] Palbociclib-d8 is labelled Palbociclib (P139900), an experimental drug for the treatment of breast cancer being developed by Pfizer. It is a selective inhibitor of the cyclin-dependent kinases CDK4 and CDK6.
[IC 50] Cdk4/cyclin D3: 9 nM (IC₅₀); Cdk4/cyclin D1: 11 nM (IC₅₀); Cdk6/cyclin D2: 16 nM (IC₅₀); DYRK1A: 2000 nM (IC₅₀); MAPK: 8000 nM (IC₅₀)

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