| Identification | Back Directory | [Name]
N-[4-[[(2-Amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid disodium salt | [CAS]
163254-40-8 | [Synonyms]
CL143
Disodium folinate
Disodium levofolinate
Folinic acid disodium
Levoleucovorin disodium
(2S)-2-[[4-[[(6S)-2-amino-5-formyl-4-oxo-1,6,7,8-tetrahydropteridin-6-yl]methylamino]benzoyl]amino]pentanedioate
N-[4-[[(2-Amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid disodium salt
N-[4-[[(2-Amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid disodium salt USP/EP/BP | [Molecular Formula]
C20H21N7Na2O7 | [MDL Number]
MFCD11618008 | [MOL File]
163254-40-8.mol | [Molecular Weight]
517.13 |
| Hazard Information | Back Directory | [Uses]
Folinic acid (Leucovorin) disodium is a biological folic acid and is a forms of vitamin B9. Folinic acid disodium is generally administered along with Methotrexate.html" class="link-product" target="_blank">Methotrexate (MTX) (HY-14519) as a rescue agent to decrease MTX-induced toxicity. Folinic acid disodium and Sfluorouracil adjuvant chemotherapy shows effective in colon carcinoma[1][2][3]. | [in vivo]
Folinic acid disodium (7.0 mg/kg; intraperitoneal injection; every second day; for 3 weeks; Balb/c young growing male mice) treatment following Methotrexate (MTX) administration appears to reverse this growth inhibition (Chronic administration of MTX induces suppression of skeletal growth in mice)[2]. | Animal Model: | 24 Balb/c young growing male mice aged 3 weeks (11.88 ± 0.25 g)[2] | | Dosage: | 7.0 mg/kg | | Administration: | Intraperitoneal injection; every second day; for 3 weeks | | Result: | Following MTX administration appears to reverse this growth inhibition. |
| [IC 50]
Human Endogenous Metabolite | [References]
[1] Keshava, C., et al., Inhibition of methotrexate-induced chromosomal damage by folinic acid in V79 cells. Mutat Res, 1998. 397(2): p. 221-8. DOI:10.1016/s0027-5107(97)00216-9
[2] Iqbal MP, et al. Effect of methotrexate and folinic acid on skeletal growth in mice. Acta Paediatr. 2003 Dec;92(12):1438-44. PMID:14971796
[3] Francini G, et al. Folinic acid and 5-fluorouracil as adjuvant chemotherapy in colon cancer. Gastroenterology. 1994 Apr;106(4):899-906. DOI:10.1016/0016-5085(94)90748-x |
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