| Identification | More | [Name]
Folic acid | [CAS]
59-30-3 | [Synonyms]
ACIDUM FOLICUM
CYTOFOL
FOLACIN
FOLIC ACID
FOLIC ACID HYDRATE
FOLSAN
FOLSAURE
INCAFOLIC
l-pteroylglutamic acid
n-4-[(2-amido-4-oxo-1,4-dihydro-6-terene)methylamino]benzoyl-l-glutamic acid
N-[4-[[(2-AMINO-4-HYDROXY-6-PTERIDYL)METHYL]AMINO]BENZOYL]GLUTAMIC ACID
PGA
PTEGLU
PTEROYGLUTAMIC ACID
PTEROYLGLUTAMIC ACID
PTEROYL-L-GLUTAMIC ACID
PTEROYLMONOGLUTAMIC ACID
Vitamin B11
VITAMIN BC
VITAMIN M | [EINECS(EC#)]
200-419-0 | [Molecular Formula]
C19H19N7O6 | [MDL Number]
MFCD00079305 | [Molecular Weight]
441.4 | [MOL File]
59-30-3.mol |
| Chemical Properties | Back Directory | [Appearance]
orange to yellow crystalline powder | [mp ]
250 °C
| [alpha ]
20 º (c=1, 0.1N NaOH) | [storage temp. ]
2-8°C
| [Stability:]
Stable. Incompatible with heavy metal ions, strong oxidizing agents, strong reducing agents. Solutions may be light and heat sensitive. | [Water Solubility ]
1.6 mg/L (25 ºC) | [Merck ]
4221 | [Uses]
Folic Acid is a water-soluble b-complex vitamin that aids in the for-
mation of red blood cells, prevents certain anemias, and is essential
in normal metabolism. high-temperature processing affects its sta-
bility. it is best stored at lower than room temperatures. it is also
termed folacin. it is found in liver, nuts, and green vegetables. | [Uses]
folic acid is generally used as an emollient. In vitro and in vivo skin studies now indicate its capacity to aid in DnA synthesis and repair, promote cellular turnover, reduce wrinkles, and promote skin firmness. There is some indication that folic acid may also protect DnA from uV-induced damage. Folic acid is a member of the vitamin B complex and is naturally occurring in leafy greens. | [Uses]
Literature tends to indicate that B vitamins cannot pass through the layers of the skin and, therefore, are of no value in the skin surface. Current experiments demonstrate, however, that vitamin B2 acts as a chemical reaction accelerator, enhancing the performance of tyrosine derivatives in suntan-accelerating preparations. | [CAS DataBase Reference]
59-30-3(CAS DataBase Reference) | [NIST Chemistry Reference]
Folic acid(59-30-3) | [EPA Substance Registry System]
59-30-3(EPA Substance) |
| Safety Data | Back Directory | [Risk Statements ]
R33:Danger of cumulative effects.
R62:Possible risk of impaired fertility.
R68:Possible risk of irreversible effects. | [Safety Statements ]
S24/25:Avoid contact with skin and eyes . | [WGK Germany ]
1
| [RTECS ]
LP5425000
| [F ]
8 | [HS Code ]
29362910 | [Safety Profile]
Poison by
intraperitoneal and intravenous routes.
Experimental teratogenic effects. Mutation
data reported. When heated to
decomposition it emits toxic fumes of NOx. | [Hazardous Substances Data]
59-30-3(Hazardous Substances Data) |
| Hazard Information | Back Directory | [General Description]
Odorless orange-yellow needles or platelets. Darkens and chars from approximately 482°F. | [Reactivity Profile]
Acid solutions of FOLIC ACID(59-30-3) are sensitive to heat, but towards neutrality, stability progressively increases. Solutions are inactivated by ultraviolet light and alkaline solutions are sensitive to oxidation. FOLIC ACID(59-30-3) is also inactivated by light. This chemical is incompatible with oxidizing agents, reducing agents and heavy metal ions. | [Air & Water Reactions]
Insoluble in water. Aqueous solutions have pHs of 4.0-4.8. | [Fire Hazard]
Flash point data for this chemical are not available; however, FOLIC ACID is probably combustible. |
| Questions And Answer | Back Directory | [Description]
Folic acid (folate) is a kind of B-vitamin which is mainly present in the liver and kidney. It has various kinds of pharmacological and physiological effects. It is involved in amino acid metabolism, purine and pyrimidine synthesis, and is also essential for hematopoiesis and red blood cell generation. In women pregnancy, folate can effectively prevent neural tube defects in the baby. It plays important role in fertility through contributing to spermatogenesis. It can also reduce the incidence of heart disease, stroke and cancer.
Folate deficiency may lead to various kinds of diseases including glossitis, diarrhea, depression, confusion, anemia, and fetal neural tube defectsand brain defects (during pregnancy). Other symptoms may include fatigue, gray hair, mouth sores, poor growth, and swollen tongue.
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