| Identification | Back Directory | [Name]
CHLOROTOXIN | [CAS]
163515-35-3 | [Synonyms]
CLTX
Tm 601
Tm-601
CHLOROTOXIN
Tm601 peptide
Chlorotoxin, >97%
CLTX (EGYPTIAN SCORPION)
Chlorotoxin trifluoroacetate salt
CHLOROTOXIN, RECOMBINANT, EXPRESSED
Chlorotoxin
Cltx (Egyptian scorpion)
chlorotoxin from leiurus quinquestriatus (north africa)
MET-CYS-MET-PRO-CYS-PHE-THR-THR-ASP-HIS-GLN-MET-ALA-ARG-LYS-CYS-ASP-ASP-CYS-CYS-GLY-GLY-LYS-GLY-ARG-GLY-LYS-CYS-TYR-GLY-PRO-GLN-CYS-LEU-CYS-ARG-NH2
H-MET-CYS-MET-PRO-CYS-PHE-THR-THR-ASP-HIS-GLN-MET-ALA-ARG-LYS-CYS-ASP-ASP-CYS-CYS-GLY-GLY-LYS-GLY-ARG-GLY-LYS-CYS-TYR-GLY-PRO-GLN-CYS-LEU-CYS-ARG-OH
H-MET-CYS-MET-PRO-CYS-PHE-THR-THR-ASP-HIS-GLN-MET-ALA-ARG-LYS-CYS-ASP-ASP-CYS-CYS-GLY-GLY-LYS-GLY-ARG-GLY-LYS-CYS-TYR-GLY-PRO-GLN-CYS-LEU-CYS-ARG-NH2
H-MET-CYS-MET-PRO-CYS-PHE-THR-THR-ASP-HIS-GLN-MET-ALA-ARG-LYS-CYS-ASP-ASP-CYS-CYS-GLY-GLY-LYS-GLY-ARG-GLY-LYS-CYS-TYR-GLY-PRO-GLN-CYS-LEU-CYS-ARG-NH2, (DISULFIDE BONDS BETWEEN CYS2 AND CYS19/CYS5 AND CYS28/CYS16 AND CYS33/CYS20 AND CYS35) | [Molecular Formula]
C158H256N52O48S11 | [MDL Number]
MFCD00239920 | [MOL File]
163515-35-3.mol | [Molecular Weight]
4004.76 |
| Chemical Properties | Back Directory | [storage temp. ]
−20°C
| [solubility ]
aqueous buffer: soluble
| [form ]
lyophilized powder
| [color ]
Colorless to light yellow | [Sequence]
Met-Cys-Met-Pro-Cys-Phe-Thr-Thr-Asp-His-Gln-Met-Ala-Arg-Lys-Cys-Asp-Asp-Cys-Cys-Gly-Gly-Lys-Gly-Arg-Gly-Lys-Cys-Tyr-Gly-Pro-Gln-Cys-Leu-Cys-Arg-NH2 (Disulfide bridge: Cys2-Cys19,Cys5-Cys28,Cys16-Cys33,Cys20-Cys35) |
| Hazard Information | Back Directory | [Uses]
Biochemical probe for voltage-gated chloride channels. | [Biological Activity]
Potent neurotoxin. Small conductance Cl- channel blocker. Highly specific marker for glioma cells and tumors of neuroectodermal origin. Inhibits the activity of matrix metalloproteinase-2 (MMP-2). | [in vivo]
Chlorotoxin shows insecticidal activity on insects and other invertebrates. After the administration of I-Chlorotoxin to tumor-bearing mice, the peptides accumulated within the tumor[2].Chlorotoxin selectively accumulates in the brain of tumor-bearing mice with calculated brain: muscle ratios of 36.4% of injected dose/g (ID/g), as compared to 12.4%ID/g in control animals[3]. | [storage]
Store at -20°C |
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