| Identification | Back Directory | [Name]
RATJADONE A | [CAS]
163564-92-9 | [Synonyms]
RATJADON
RATJADONE
RATJADONE A
2H-Pyran-2-one, 5,6-dihydro-6-[(1E,3Z,5R,7E,9E,11R)-11-hydroxy-3,5,7-trimethyl-11-[(2S,4R,5S,6S)-tetrahydro-4-hydroxy-5-methyl-6-(1E)-1-propen-1-yl-2H-pyran-2-yl]-1,3,7,9-undecatetraen-1-yl]-, (6R)- | [Molecular Formula]
C28H40O5 | [MDL Number]
MFCD32705544 | [MOL File]
163564-92-9.mol | [Molecular Weight]
456.61 |
| Chemical Properties | Back Directory | [storage temp. ]
-70°C | [solubility ]
aqueous buffer: ≤100μM
methanol: 20mg/mL | [form ]
Clear liquid. | [InChIKey]
CAYGMWMWJUFODP-AYFTZVAISA-N | [SMILES]
O1[C@H]([C@H]([C@@H](C[C@H]1[C@H](O)\C=C\C=C(\C[C@@H](C)\C=C(\C)/C=C/[C@@H]2OC(=O)C=CC2)/C)O)C)\C=C\C |
| Safety Data | Back Directory | [WGK Germany ]
WGK 2 | [Storage Class]
3 - Flammable liquids | [Hazard Classifications]
Acute Tox. 3 Dermal
Acute Tox. 3 Inhalation
Acute Tox. 3 Oral
Flam. Liq. 2
STOT SE 1 |
| Hazard Information | Back Directory | [Uses]
Ratjadone A, Synthetic is a cell-permeable polyketide that inhibits cell proliferation. | [Biological Activity]
Cell permeable: yes''Primary Target
nuclear export of LR-NES''Product does not compete with ATP.''Reversible: no''Target IC50: ≤ 1 ng/ml for inhibiting proliferation and inducing cell cycle arrest at G1 phase |
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