| Identification | Back Directory | [Name]
2,4,6,8,12,18,20,22,24,26,38,48,52-Hexacontatridecaenoicacid, 60-amino-15,17,29,33,35,37,41,43,45,47,51,55,57-tridecahydroxy-2,14,16,30-tetramethyl-31-oxo-,(2E,4E,6E,8E,12E,15S,16S,17R,18E,20E,22E,24E,26E,35S,37S,38E,41R,43S,45R,47S,48E,52E,55S,57R)- | [CAS]
163596-98-3 | [Synonyms]
Linearmycin A
2,4,6,8,12,18,20,22,24,26,38,48,52-Hexacontatridecaenoicacid, 60-amino-15,17,29,33,35,37,41,43,45,47,51,55,57-tridecahydroxy-2,14,16,30-tetramethyl-31-oxo-,(2E,4E,6E,8E,12E,15S,16S,17R,18E,20E,22E,24E,26E,35S,37S,38E,41R,43S,45R,47S,48E,52E,55S,57R)- | [Molecular Formula]
C64H101NO16 | [MOL File]
163596-98-3.mol | [Molecular Weight]
1140.48 |
| Hazard Information | Back Directory | [Uses]
Linearmycin A is a polyene antibiotic that has been found in Streptomyces. It is active against the bacteria S. aureus and E. coli (MICs=3.1 and 1.6 μg/disc, respectively), the fungi S. cerevisiae and C. albicans (MICs=0.1 and 1.6 μg/disc, respectively), and the plant pathogenic fungus A. niger in disc assays (MIC=0.2 μg/disc). Linearmycin A induces lysis and degradation of B. subtilis as a component of Streptomyces Mg1 extract. | [Biological Activity]
Linearmycin A is a polyene antibiotic that has been found in Streptomyces.1 It is active against the bacteria S. aureus and E. coli (MICs = 3.1 and 1.6 μg/disc, respectively), the fungi S. cerevisiae and C. albicans (MICs = 0.1 and 1.6 μg/disc, respectively), and the plant pathogenic fungus A. niger in disc assays (MIC = 0.2 μg/disc). Linearmycin A induces lysis and degradation of B. subtilis as a component of Streptomyces Mg1 extract.2 | [storage]
-20°C | [References]
1.Sakuda, S., Guce-Bigol, U., Itoh, M., et al.Novel linear polyene antibiotics: LinearmycinsJ. Chem. Soc., Perkin Trans. 1182315-2319(1996)
2.Stubbendieck, R.M., and Straight, P.D.Escape from lethal bacterial competition through coupled activation of antibiotic resistance and a mobilized subpopulationPLoS Genet.11(12)e1005722(2015)
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