| Identification | Back Directory | [Name]
[1(2H),4'-Bipyridin]-2-one, 3-chloro-4-[(3,5-difluoro-2-pyridinyl)methoxy]-2'-[2-(1-hydroxy-1-methylethyl)-4-pyrimidinyl]-5',6-dimethyl-, (2'S)- | [CAS]
1640282-42-3 | [Synonyms]
ATI-450
Zunsemetinib
[1(2H),4'-Bipyridin]-2-one, 3-chloro-4-[(3,5-difluoro-2-pyridinyl)methoxy]-2'-[2-(1-hydroxy-1-methylethyl)-4-pyrimidinyl]-5',6-dimethyl-, (2'S)- | [Molecular Formula]
C25H22ClF2N5O3 | [MOL File]
1640282-42-3.mol | [Molecular Weight]
513.93 |
| Chemical Properties | Back Directory | [Boiling point ]
680.4±55.0 °C(Predicted) | [density ]
1.45±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO:100.0(Max Conc. mg/mL);194.58(Max Conc. mM) | [form ]
Solid | [pka]
13.52±0.29(Predicted) | [color ]
White to yellow |
| Hazard Information | Back Directory | [Uses]
Zunsemetinib (CDD-450) is an orally active and selective p38α mitogen-activated protein kinase-activated protein kinase 2 (MK2) pathway inhibitor. Zunsemetinib can be used for the research of immuno-inflammatory diseases[1]. | [in vivo]
Zunsemetinib (1,000 ppm; p.o.) blocks LPS-induced TNF-α expression persisted for up to 4 weeks after dosing[1].
Zunsemetinib (10 and 20 mg/kg; p.o.) increases bone density[1].
Zunsemetinib prevents osteopenia in NOM IDc mice through inhibition of osteoclastogenesis[1]. | Animal Model: | 8-week-old WT female mice[1] | | Dosage: | 1,000 ppm | | Administration: | P.o. | | Result: | Blocked LPS-induced TNF-α expression persisted for up to 4 weeks after dosing.
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| Animal Model: | Rats[1] | | Dosage: | 10 and 20 mg/kg | | Administration: | P.o. | | Result: | Increased bone density.
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| [storage]
Store at -20°C | [References]
[1] Zunsemetinib (ATI-450) – Investigational oral MK2 pathway inhibitor
[2] Aclaris Therapeutics Announces ATI-450 (MK2 pathway Inhibitor) publication in Journal of Experimental Medicine
[3] Wang C, et al. Selective inhibition of the p38α MAPK-MK2 axis inhibits inflammatory cues including inflammasome priming signals. J Exp Med. 2018;215(5):1315-1325. DOI:10.1084/jem.20172063 |
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| Company Name: |
DC Chemicals
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| Tel: |
021-58447131 13564518121 |
| Website: |
https://www.chemicalbook.com/ShowSupplierProductsList927327/0.htm |
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