| Identification | Back Directory | [Name]
TLR7-IN-1 | [CAS]
1642857-69-9 | [Synonyms]
CS-2748
TLR7-IN-1
TLR7-agonist-1
TLR7 agonist 2
inhibit,TLR7 agonist 2,TLR-7 agonist 2,Inhibitor,Toll-like Receptor (TLR)
5H-Pyrrolo[3,2-d]pyrimidin-2-amine, 4-[(5-methyl-3-isoxazolyl)methoxy]-5-(2-pyridinylmethyl)-
4-[(5-methyl-1,2-oxazol-3-yl)methoxy]-5-[(pyridin-2-yl)methyl]-5H-pyrrolo[3,2-d]pyrimidin-2-amine | [Molecular Formula]
C17H16N6O2 | [MDL Number]
MFCD31729282 | [MOL File]
1642857-69-9.mol | [Molecular Weight]
336.35 |
| Chemical Properties | Back Directory | [Melting point ]
147 - 149°C | [Boiling point ]
655.1±65.0 °C(Predicted) | [density ]
1.45±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C Freezer, Under inert atmosphere | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
6.89±0.30(Predicted) | [color ]
White to Off-White |
| Hazard Information | Back Directory | [Uses]
TLR7-agonist-1, is a potent and selective Toll-like Receptor 7 (TLR7) agonist with a LEC of 0.4 μM. | [in vivo]
TLR7 agonist 2 is found to be rapidly cleared in conjunction with our target profile. Both Cmax and AUC increase less than dose proportionally between 0.3 and 3 mg/kg and more than dose-proportionally between 3 and 10 mg/kg. TLR7 agonist 2 can induce an antiviral interferon stimulated gene (ISG) response without inducing an IFNα response at a low dose. TLR7 agonist 2 also induces a 2.7 log decrease in serum HBV viral load from 0.3 mg/kg, and a maximum 3.1 log decrease is observed for doses between 1 and 5 mg/kg[1]. |
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Twochem Co.Ltd.
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Cckinase, Inc.
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www.cckinase.com |
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cjbscvictory
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