| Identification | Back Directory | [Name]
Fosnetupitant chloride hydrochloride | [CAS]
1643757-72-5 | [Synonyms]
Fosnetupitant hydrochloride
Fosnetupitant chloride hydrochloride | [Molecular Formula]
C31H37Cl2F6N4O5P | [MOL File]
1643757-72-5.mol | [Molecular Weight]
761.52 |
| Hazard Information | Back Directory | [Uses]
Fosnetupitant chloride monohydrochloride (Pronetupitant chloride monohydrochloride) is an NK1 antagonist with pKi values of 9.5, 6.1 for human NK1 and NK3?receptor, respectively. Fosnetupitant chloride monohydrochloride is a methylene phosphate prodrug of Netupitant[1]. | [in vivo]
Fosnetupitant chloride monohydrochloride (i.v.) is converted in few minutes to Netupitant (HY-16346) invivo[1]. | [IC 50]
hNK1: 9.5 (pKi); hNK3: 6.1 (pKi) | [References]
[1] Ruzza C, et al. In vitro and in vivo pharmacological characterization of Pronetupitant, a prodrug of the neurokinin 1 receptor antagonist Netupitant. Peptides. 2015 Jul;69:26-32. DOI:10.1016/j.peptides.2015.03.021 |
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