| Identification | Back Directory | [Name]
KP 103 | [CAS]
164650-44-6 | [Synonyms]
KP 103
Jublia
Efinaconzole
Efluconazole
Efinaconazole
KP 103 USP/EP/BP
Efinaconazole 13CD2
Efinaconazole 13CD6
Efinaconazole(KP 103)
JUBLIA; KP 103; KP103
Efinaconazole
(Jublia)
Efinaconazole In-House
KP 103 (pharmaceutical)
(R,R)-2-(2,4-Difluorophenyl)-3-(4-methylenepiperidin-1-yl)-1-(1,2,4-triazol-1-yl)-2-butanol
Efinaconazole D4Q: What is
Efinaconazole D4 Q: What is the CAS Number of
Efinaconazole D4
(2R,3R)-2-(2,4-Difluorophenyl)-3-(4-methylenepiperidin-1-yl)-1-(1,2,4-triazol-1-yl)-2-butanol
(αR,βR)-α-(2,4-Difluorophenyl)-β-methyl-4-methylene-α-(1H-1,2,4-triazol-1-ylmethyl)-1-piperidineethanol
1-Piperidineethanol, α-(2,4-difluorophenyl)-β-methyl-4-methylene-α-(1H-1,2,4-triazol-1-ylmethyl)-, (αR,βR)-
(2R,3R)-2-(2,4-Difluorophenyl)-3-(4-methylenepiperidin-1-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol (Efinaconazole)
(alphaR,betaR)-alpha-(2,4-Difluorophenyl)-beta-methyl-4-methylene-alpha-(1H-1,2,4-triazol-1-ylmethyl)-1-piperidineethanol
EfinaconazoleQ: What is
Efinaconazole Q: What is the CAS Number of
Efinaconazole Q: What is the storage condition of
Efinaconazole Q: What are the applications of
Efinaconazole | [EINECS(EC#)]
813-597-5 | [Molecular Formula]
C18H22F2N4O | [MDL Number]
MFCD00936406 | [MOL File]
164650-44-6.mol | [Molecular Weight]
348.39 |
| Chemical Properties | Back Directory | [Melting point ]
192-195°C | [Boiling point ]
512.2±60.0 °C(Predicted) | [density ]
1.26±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
Chloroform (Slightly), Methanol (Slightly) | [form ]
powder | [pka]
12.11±0.29(Predicted) | [color ]
white to beige | [Optical Rotation]
[α]/D -85 to -95°, c = 1 in chloroform | [InChI]
InChI=1/C18H22F2N4O/c1-13-5-7-23(8-6-13)14(2)18(25,10-24-12-21-11-22-24)16-4-3-15(19)9-17(16)20/h3-4,9,11-12,14,25H,1,5-8,10H2,2H3/t14-,18-/s3 | [InChIKey]
NFEZZTICAUWDHU-GKGMEZMPNA-N | [SMILES]
N1([C@H](C)[C@@](C2=CC=C(F)C=C2F)(CN2C=NC=N2)O)CCC(=C)CC1 |&1:1,3,r| |
| Hazard Information | Back Directory | [Description]
In October 2013, efinaconazole (also known as KP-103) was approved in Canada as a 10% topical solution for the treatment of onychomycosis. Like other azole antifungal agents, efinaconazole acts by disrupting fungal cell membranes through inhibition of sterol 14α-demethylase, an enzyme involved in the biosynthesis of ergosterol, which is a key component of the fungal cell membrane. Efinaconazole has potent antifungal activity against clinical isolates of dermatophytes, including Trichophyton mentagrophyes (MIC80 =0.125 μg/mL) and Trichophyton rubrum (MIC80 =0.25 μg/mL), as well as against Candida and Malassezia species. Unlike other antifungal agents, efinaconazole retains activity in the presence of keratin, indicating that more unbound drug is available at the site of action. Efinaconazole is efficacious in guinea-pig models of fungal infection. Efinaconazole is prepared by reaction of an epoxide intermediate with 4-methylenepiperidine. | [Originator]
Kaken Pharmaceuticals (Japan) | [Uses]
Efinaconazole has been used as:
- a topical anti-onychomycosis drug to determine its effects on Trichophyton rubrum and Trichophyton interdigitale
- as an anti-fungal agent to study its permeability into the nail lysates
- as an anti-fungal agent to study its effects on Candida africana and Candida dubliniensis
| [Definition]
ChEBI: A member of the class of triazoles that is butan-2-ol which is substituted at positions 1, 2, and 3 by 1,2,4-triazol-1-yl, 2,4-difluorophenyl, and 4-methylenepiperidin-1-yl groups, respectively (the 2R,3R stereoisomer). It
is an antifungal drug used for the topical treatment of onychomycosis (a nail infection caused mainly by dermatophytes). | [Brand name]
Jublia | [Biochem/physiol Actions]
Efinaconazole is a triazole antifungal drug approved clinically for the treatment of nail fungus (Onychomycosis). It inhibits sterol biosynthesis by inhibition of cytochrome P450 14α-demethylase, an enzyme in the sterol biosynthesis pathway that leads from lanosterol to ergosterol. Efinaconazole has better nail penetration, so is more effective than other topical agents and as effective as oral medication for nail fungus. | [Synthesis]
Commercially available (R)-methyl lactate (55) was first converted
to THP protected alcohol 57 in 4 steps and 78% yield via
morpholino amide 56. Grignard displacement of the morpholine
afforded ketone 58 in 81% yield. Next, ketone 58 was epoxidized
by means of the Corey ylide followed by ring-opening of the epoxide
by triazole which had been activated by exposure to sodium tbutoxide.
Finally, subjection to methanesulfonic acid furnished
diol 59 in 51% yield as the corresponding mesylate salt. Diol 59
was then converted to epoxide 60 through the use of mesyl chloride
and triethylamine in 78% yield and >99% ee. Finally, treatment of epoxide 60 with 4-methylene piperidine¨CHBr in the presence of
lithium hydroxide afforded efinaconazole (VIII) in 87% yield.
| [storage]
Store at -20°C | [References]
[1] WILLIAM J JO SIU. Comparison of in vitro antifungal activities of efinaconazole and currently available antifungal agents against a variety of pathogenic fungi associated with onychomycosis.[J]. Antimicrobial Agents and Chemotherapy, 2013, 57 4: 1610-1616. DOI: 10.1128/aac.02056-12
[2] YOSHIYUKI TATSUMI. Mechanism of action of efinaconazole, a novel triazole antifungal agent.[J]. Antimicrobial Agents and Chemotherapy, 2013, 57 5: 2405-2409. DOI: 10.1128/aac.02063-12 |
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| Company Name: |
Jia Xing Isenchem Co.,Ltd
|
| Telephone: |
0573-85285100 18627885956 |
| Website: |
https://www.chemicalbook.com/ShowSupplierProductsList14265/0_EN.htm |
| Company Name: |
Adamas Reagent, Ltd.
|
| Telephone: |
4006009262 13023226327 |
| Website: |
http://www.tansoole.com |
|