| Identification | Back Directory | [Name]
Dihydrodutasteride | [CAS]
164656-22-8 | [Synonyms]
Dihydrodutasteride
Dutasteride Dihydro
Dihydro Dutasteride
Dutasteride Dihydro Imp
Dutasteride Dihydro Impurity
(5α,17β)-N-[2,5-Bis
(trifluoroMethyl)phenyl]-3-oxo-4-azaandrostane-17-carboxaMide
(5α,17β)-N-[2,5-bis(trifluoromethyl)-phenyl]-3-oxo-4-aza-5-androstane-17-carboxamide
(4aR,4bS,6aS,7S,9aS,9bS,11aR)-N-[2,5-Bis(trifluoroMethyl)phenyl]hexadecahydro-4a,6a-diMethyl-2-oxo-1H-Indeno[5,4-f]quinoline-7-carboxaMide
1H-Indeno[5,4-f]quinoline-7-carboxamide, N-[2,5-bis(trifluoromethyl)phenyl]hexadecahydro-4a,6a-dimethyl-2-oxo-, (4aR,4bS,6aS,7S,9aS,9bS,11aR)- | [Molecular Formula]
C27H32F6N2O2 | [MDL Number]
MFCD24386648 | [MOL File]
164656-22-8.mol | [Molecular Weight]
530.546 |
| Chemical Properties | Back Directory | [Melting point ]
>213oC (dec.) | [Boiling point ]
613.8±55.0 °C(Predicted) | [density ]
1.286±0.06 g/cm3(Predicted) | [storage temp. ]
Refrigerator | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
13.33±0.70(Predicted) | [color ]
White |
| Hazard Information | Back Directory | [Uses]
Dihydro Dutasteride is an impurity arose during the process development of Dutasteride (D735000). | [Synthesis]
16.65 g of methyl 3-keto-4-aza-5α-androsta-17β-carboxylate was dissolved in 250 ml of dichloromethane and 18.95 ml of boron tribromide was added dropwise under cooling in room temperature water (25 °C). Stirring was continued at room temperature for 20 mi |
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