| Identification | Back Directory | [Name]
3-[[4-[2-[(3-Chlorophenyl)amino]-4-pyrimidinyl]-2-pyridinyl]amino]-1-propanol | [CAS]
164658-13-3 | [Synonyms]
CS-506
CGP 60474
CGP-60474;CGP 60474
3-[[4-[2-(3-chloroanilino)pyrimidin-4-yl]pyridin-2-yl]amino]propan-1-ol
3-[[4-[2-[(3-Chlorophenyl)amino]-4-pyrimidinyl]-2-pyridinyl]amino]-1-propanol
1-Propanol, 3-[[4-[2-[(3-chlorophenyl)amino]-4-pyrimidinyl]-2-pyridinyl]amino]- | [EINECS(EC#)]
200-258-5 | [Molecular Formula]
C18H18ClN5O | [MDL Number]
MFCD00938945 | [MOL File]
164658-13-3.mol | [Molecular Weight]
355.82 |
| Chemical Properties | Back Directory | [Melting point ]
144-147℃ | [Boiling point ]
630.6±65.0 °C(Predicted) | [density ]
1.356 | [storage temp. ]
Keep in dark place,Sealed in dry,2-8°C | [solubility ]
Soluble in DMSO | [form ]
Powder | [pka]
14.93±0.10(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
CGP 60474 is type of protein kinase C inhibitor (ckd1/cdk2) used in the treatment of different cancers | [Definition]
ChEBI:3-[[4-[2-(3-chloroanilino)-4-pyrimidinyl]-2-pyridinyl]amino]-1-propanol is a substituted aniline. | [in vivo]
CGP-60474 (10?mg/kg; i.p.) inhibits the IL-6 level and increases the survival rate in the LPS endotoxemia model[2]. | Animal Model: | C57Bl/6 mice (LPS endotoxemia model)[2] | | Dosage: | 10?mg/kg | | Administration: | I.p. | | Result: | Had a higher survival rate.
|
| [IC 50]
CDK1-Cyclin B: 26 nM (IC50); CDK2/cyclinE: 3 nM (IC50); cdk2/cyclin A: 4 nM (IC50); CDK4/cyclin D: 216 nM (IC50); Cdk5/p25: 10 nM (IC50); CDK7/cyclin H: 200 nM (IC50); CDK9/cycT: 13 nM (IC50); PKC | [storage]
Store at -20°C |
|
| Company Name: |
LETOPHARM LIMITED
|
| Telephone: |
+86-21-5821 5861 |
| Website: |
www.letopharm.com |
|