| Identification | Back Directory | [Name]
Urolithin C | [CAS]
165393-06-6 | [Synonyms]
Urolithin C
3,8,9-Trihydroxy-6H-benzo[c]chromen-6-one
3,8,9-Trihydroxy-6H-dibenzo[b,d]pyran-6-one
6H-Dibenzo[b,d]pyran-6-one, 3,8,9-trihydroxy- | [Molecular Formula]
C13H8O5 | [MDL Number]
MFCD20275232 | [MOL File]
165393-06-6.mol | [Molecular Weight]
244.2 |
| Chemical Properties | Back Directory | [Melting point ]
>300°C | [Boiling point ]
605.4±55.0 °C(Predicted) | [density ]
1.640±0.06 g/cm3(Predicted) | [storage temp. ]
Inert atmosphere,Room Temperature | [solubility ]
DMSO (Slightly), Methanol (Slightly, Heated) | [form ]
Solid | [pka]
7.51±0.20(Predicted) | [color ]
Off-White to Pale Brown | [Stability:]
Hygroscopic | [InChIKey]
HHXMEXZVPJFAIJ-UHFFFAOYSA-N | [SMILES]
O=C1C2=CC(O)=C(O)C=C2C3=C(C=C(O)C=C3)O1 | [LogP]
1.615 (est) |
| Hazard Information | Back Directory | [Uses]
Urolithin C is used in biological studies to evaluate the metabolite antioxidant activity. | [Definition]
ChEBI: Urolithin C is a member of coumarins. | [Biological Activity]
Urolithin C is chebulic ellagitannins metabolite th at exerts antiproliferative and antioxidant activity. Urolithin C exhibit glucose dependent enhancement of insulin secretion in islet cells under normal or dysfunctional conditions. Apparentlyit facilitates L-type Ca2+ channel opening and Ca2+ influx into pancreatic β-cells. | [in vivo]
The pharmacokinetics of Urolithin C (10 mg/kg; intraperitoneal administration) in male Wistar rat (140-160 g) are studied. The half-life of the terminal part is 11.3 h and the total clearance (CL/F) is 3.41 L/h/kg. The initial volume of distribution (V1/F) and the steady-state volume of distribution (Vss/F) are 0.831 L/kg and 55.6 L/kg, respectively[3]. | [IC 50]
L-type calcium channel |
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