| Identification | Back Directory | [Name]
UROCORTIN (RAT) | [CAS]
171543-83-2 | [Synonyms]
Rat urocortin
UROCORTIN (RAT)
Urocortin (sheep)
Urocortin 1 (rat)
PubChem ID: 90479814
Urocortin ratUrocortin
UROCORTIN (RAT) (MOUSE)
Urocortin rat, ≥97% (HPLC)
UROCORTIN (RAT) (FREE ACID)
M.W. 4707.26 C206H338N62O64
Urocortin (Rattus norvegicus)
Urocortin rat >=97% (HPLC), powder
Urocortin(Rattus norvegicus) (9CI)
Urocortin (rat) (trifluoroacetate salt)
DDPPLSIDLTFHLLRTLLELARTQSQRERAEQNRIIFDSV-NH2
ASP-ASP-PRO-PRO-LEU-SER-ILE-ASP-LEU-THR-PHE-HIS-LEU-LEU-ARG-THR-LEU-LEU-GLU-LEU-ALA-ARG-THR-GLN-SER-GLN-ARG-GLU-ARG-ALA-GLU-GLN-ASN-ARG-ILE-ILE-PHE-ASP-SER-VAL
ASP-ASP-PRO-PRO-LEU-SER-ILE-ASP-LEU-THR-PHE-HIS-LEU-LEU-ARG-THR-LEU-LEU-GLU-LEU-ALA-ARG-THR-GLN-SER-GLN-ARG-GLU-ARG-ALA-GLU-GLN-ASN-ARG-ILE-ILE-PHE-ASP-SER-VAL-NH2
H-ASP-ASP-PRO-PRO-LEU-SER-ILE-ASP-LEU-THR-PHE-HIS-LEU-LEU-ARG-THR-LEU-LEU-GLU-LEU-ALA-ARG-THR-GLN-SER-GLN-ARG-GLU-ARG-ALA-GLU-GLN-ASN-ARG-ILE-ILE-PHE-ASP-SER-VAL-OH
H-ASP-ASP-PRO-PRO-LEU-SER-ILE-ASP-LEU-THR-PHE-HIS-LEU-LEU-ARG-THR-LEU-LEU-GLU-LEU-ALA-ARG-THR-GLN-SER-GLN-ARG-GLU-ARG-ALA-GLU-GLN-ASN-ARG-ILE-ILE-PHE-ASP-SER-VAL-NH2 | [Molecular Formula]
C206H338N62O64 | [MDL Number]
MFCD00678232 | [MOL File]
171543-83-2.mol | [Molecular Weight]
4707.26 |
| Chemical Properties | Back Directory | [storage temp. ]
-20°C | [solubility ]
1% acetic acid: >1 mg/mL, clear, colorless
| [form ]
powder
| [color ]
White to off-white | [biological source]
rat | [Water Solubility ]
Soluble to 1 mg/ml in water | [Sequence]
Asp-Asp-Pro-Pro-Leu-Ser-Ile-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Thr-Leu-Leu-Glu-Leu-Ala-Arg-Thr-Gln-Ser-Gln-Arg-Glu-Arg-Ala-Glu-Gln-Asn-Arg-Ile-Ile-Phe-Asp-Ser-Val-NH2 |
| Hazard Information | Back Directory | [Uses]
Urocortin rat can be used for western blotting. The product can also be used for studying that whether CRF receptor type 2 (CRF2) and its high-affinity ligand, urocortin 1 (Ucn1) can mediate sex-specific cellular stress responses by using corticotropin-releasing factor receptor 2-deficient (Crhr2-/- ) and wild-type (WT) mice. | [Biochem/physiol Actions]
Urocortin is a CRF-related neuropeptide that binds to CRF receptor types 1α, 2α and 2β. It possesses appetite-suppressing effect. Urocortin along with corticotropin-releasing factor (CRF) binding protein (CRF-BP) enhances the free CRF levels in human brain by displacing hCRF from the binding protein. | [in vivo]
Urocortin, rat (0.01 to 10 μg) decreases food intake in both food-deprived and non-deprived rats and such an effect also observed in mice after 1 μg of Urocortin, rat i.c.v. administration. Urocortin, rat has the potential of inducing anxiogenic behavior[3]. | [IC 50]
CRFR1; CRFR2 |
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| Company Name: |
Sigma-Aldrich
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021-61415566 800-8193336 |
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https://www.sigmaaldrich.cn |
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